CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS.

Abstract

BACKGROUND:

Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored.

MATERIALS AND METHODS:

The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory components, and antioxidant activities.

RESULTS:

The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size.

CONCLUSION:

The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties.

• Authors: Yang Wang, Weihao Wang, Weijun Peng, Weiping Liu, Weijun Cai, Zian Xia, Honggeng Zhang, And Zhihua Xing
• Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM (Afr J Tradit Complement Altern Med) Vol. 14 Issue 2 Pg. 65-74 ( 2017) ISSN: 2505-0044 [Electronic] Nigeria
• PMID: 28573223 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Cardiotonic Agents
• Drugs, Chinese Herbal
• Interleukin-6
• Interleukin-10
• C-Reactive Protein
• Peroxidase
• Superoxide Dismutase

Topics

• Acute Disease
• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Antioxidants (metabolism, pharmacology, therapeutic use)
• C-Reactive Protein (metabolism)
• Cardiotonic Agents (pharmacology, therapeutic use)
• Coronary Vessels
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Infarction (prevention & control)
• Inflammation (blood, prevention & control)
• Interleukin-10 (metabolism)
• Interleukin-6 (metabolism)
• Male
• Myocardial Infarction (drug therapy, etiology, metabolism, pathology)
• Myocardium (metabolism, pathology)
• Oxidative Stress (drug effects)
• Peroxidase (blood)
• Phytotherapy
• Rats, Sprague-Dawley
• Superoxide Dismutase (metabolism)