Abstract | PURPOSE: METHODS: Literature searches were last conducted on January 31, 2017, in PubMed with no date restrictions and limited to articles published in English, and in the Cochrane Database without language limitations. The searches yielded 321 citations, of which 109 were reviewed in full text and 27 were deemed appropriate for inclusion in this assessment. The panel methodologist assigned ratings to the selected studies according to the level of evidence. RESULTS: CONCLUSIONS: Current level I evidence suggests that intravitreal pharmacotherapy with anti- VEGF agents is effective and safe for ME secondary to BRVO. Prolonged delay in treatment is associated with less improvement in visual acuity (VA). Level I evidence also indicates that intravitreal corticosteroids are effective and safe for the management of ME associated with BRVO; however, corticosteroids are associated with increased potential ocular side effects (e.g., elevated intraocular pressure, cataracts). Laser photocoagulation remains a safe and effective therapy, but VA results lag behind the results for anti- VEGF therapies.
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Authors | Justis P Ehlers, Stephen J Kim, Steven Yeh, Jennifer E Thorne, Prithvi Mruthyunjaya, Scott D Schoenberger, Sophie J Bakri |
Journal | Ophthalmology
(Ophthalmology)
Vol. 124
Issue 9
Pg. 1412-1423
(09 2017)
ISSN: 1549-4713 [Electronic] United States |
PMID | 28551163
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Angiogenesis Inhibitors
- Drug Implants
- Dexamethasone
|
Topics |
- Academies and Institutes
- Angiogenesis Inhibitors
(therapeutic use)
- Databases, Factual
- Dexamethasone
(therapeutic use)
- Drug Implants
- Drug Therapy, Combination
- Humans
- Intravitreal Injections
- Macular Edema
(drug therapy, etiology, physiopathology)
- Ophthalmology
(organization & administration)
- Retinal Vein Occlusion
(complications, drug therapy, physiopathology)
- Technology Assessment, Biomedical
- United States
- Visual Acuity
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