Abstract | BACKGROUND: CASE PRESENTATION: We report the case of an immunocompromised patient infected by Human Immunodeficiency Virus (HIV) with naso-maxillar histoplasmosis in a non-endemic country. Our aim is to describe the clinical presentation, the diagnostic and therapeutic issues. A 53-year-old woman, originated from Haiti, was admitted in 2016 for nasal deformation with alteration of general condition evolving for at least 6 months. HIV infection was diagnosed in 2006 and classified at AIDS stage in 2008 due to cytomegalovirus infection associated with pulmonary histoplasmosis. At admission, CD4 cell count was 9/mm3. Surgical biopsies were performed and ruled out differential or associated diagnoses. Mycological cultures identified Hcc and Blood Polymerase Chain Reaction (PCR) for Hcc was positive. The patient was given daily Amphothericin B liposomal infusion during 1 month. Hcc PCR became negative in the blood under treatment, and then oral switch by itraconazole was introduced. Antiretroviral treatment was reintroduced after a 3-week histoplasmosis treatment. Normalization of naso-maxillar mucosa enabled a palatal prosthesis. CONCLUSION: Naso-maxillar histoplasmosis is extremely rare; this is the first case ever reported in a non-endemic country. Differential diagnoses must be ruled out by conducting microbiologic tools and histological examinations on surgical biopsies. Early antifungal treatment should be initiated in order to prevent DH severe outcomes.
|
Authors | A C Lehur, M Zielinski, J Pluvy, V Grégoire, S Diamantis, A Bleibtreu, C Rioux, A Picard, D Vallois |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 17
Issue 1
Pg. 328
(05 05 2017)
ISSN: 1471-2334 [Electronic] England |
PMID | 28476105
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Anti-HIV Agents
- Antifungal Agents
- Itraconazole
|
Topics |
- AIDS-Related Opportunistic Infections
(drug therapy, etiology, microbiology)
- Acquired Immunodeficiency Syndrome
(drug therapy)
- Anti-HIV Agents
(therapeutic use)
- Antifungal Agents
(therapeutic use)
- CD4 Lymphocyte Count
- Cytomegalovirus Infections
(diagnosis, etiology)
- Diagnosis, Differential
- Female
- HIV Infections
(complications, drug therapy)
- Haiti
- Histoplasmosis
(diagnosis, drug therapy, etiology)
- Humans
- Immunocompromised Host
- Itraconazole
(therapeutic use)
- Lung Diseases, Fungal
(diagnosis, drug therapy, etiology)
- Maxillary Diseases
(drug therapy, etiology, microbiology)
- Middle Aged
- Osteolysis
(etiology, microbiology)
|