Abstract | CONCLUSIONS: OBJECTIVES: METHODS:
Cholesteatoma specimens were obtained from 38 patients with acquired cholesteatoma. The levels of expression of various CLR mRNAs were assessed quantitatively using real-time RT-PCR (Reverse transcription polymerase chain reaction) and correlated with age, sex, the presence of bacteria, hearing level, frequency of surgery, and degree of ossicle destruction. RESULTS: The levels of CD206 ( cluster of differentiation 206), DEC-205 (Dendritic and epithelial cell-205), MGL ( monoacylglycerol lipase), CLEC5A ( C-type lectin domain family 5 member A), Dectin-2 (dendrite cell-associated C-type lectin-2), BDCA2 (Blood dendritic cell antigen 2), Mincle, DCIR (dendritic cell immunoreceptor), Dectin-1, MICL (Myeloid inhibitory C type-like lectin), and CLEC12B ( C-type lectin domain family 12, member B) mRNAs were significantly higher in cholesteatoma than in control skin samples (p < 0.05). The levels of CLEC5A ( C-type lectin domain family 5 member) and Dectin-1 mRNAs were significantly higher in cholesteatomas with ≥2 than ≤1 destroyed ossicles (p < 0.05), and the levels of MGL, Mincle, Dectin-1, and CLEC12B mRNAs were significantly higher in recurrent than initial cholesteatoma specimens (p < 0.05). The level of CLEC5A mRNAs was significantly higher in patients with severe than mild-to-moderate hearing loss (p < 0.05).
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Authors | Sang Hoon Kim, Seung-Ho Han, Jae Yong Byun, Moon Suh Park, Young Il Kim, Seung Geun Yeo |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 137
Issue 6
Pg. 581-587
(Jun 2017)
ISSN: 1651-2251 [Electronic] England |
PMID | 28440726
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Cholesteatoma, Middle Ear
(complications, metabolism)
- Chronic Disease
- Female
- Humans
- Lectins, C-Type
(metabolism)
- Male
- Middle Aged
- Otitis Media
(complications, metabolism)
- Young Adult
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