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Hearing Loss (Hearing Impairment)

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A general term for the complete or partial loss of the ability to hear from one or both ears.

Also Known As:

Hearing Impairment; Hypoacusis; Hypoacuses; Loss, Hearing

Networked: 3944 relevant articles (183 outcomes, 428 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Tinnitus
2.	Deafness (Deaf Mutism)
3.	Vertigo (Positional Vertigo)
4.	Bacterial Meningitis
5.	Dizziness (Lightheadedness)

Experts

1.	Guan, Min-Xin: 29 articles (06/2010 - 01/2004)
2.	Smith, Richard J H: 22 articles (03/2010 - 05/2002)
3.	Cremers, Cor W R J: 21 articles (04/2010 - 01/2002)
4.	Han, Dongyi: 18 articles (11/2009 - 09/2003)
5.	Van Camp, Guy: 17 articles (06/2010 - 05/2002)
6.	Avraham, Karen B: 16 articles (09/2010 - 03/2002)
7.	Dai, Pu: 16 articles (11/2009 - 05/2005)
8.	Yang, Li: 14 articles (06/2010 - 02/2005)
9.	Qian, Yaping: 13 articles (11/2009 - 12/2004)
10.	Zhu, Yi: 12 articles (06/2010 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hearing Loss:

1.	Dexamethasone (Maxidex)FDA LinkGeneric 04/01/1996 - "The initial response to dexamethasone perfusion plus intravenous dexamethasone has been very good, with very little risk of further hearing loss, and it holds great promise for the future." 09/01/1989 - "Based on statistically combined results of the three most recent trials, there is evidence that dexamethasone reduces the risk of bilateral moderate or more severe hearing loss (risk difference, -9%; 95% confidence limits, -15% and -3%). " 03/01/2010 - "However, dexamethasone seemed to reduce hearing loss among survivors (24.1%vs 29.5%; 0.77, 0.60-0.99, p=0.04). " 08/01/2009 - "Use of intratympanic dexamethasone for the therapy of low frequency hearing loss." 06/01/2009 - "Dexamethasone was associated with fewer episodes of hearing impairment in high quality RCTs (OR = 0.64, 95% CI 0.43-0.94). " Order ALL the reference details at left...
2.	Cisplatin (Platino)FDA LinkGeneric 11/28/1999 - "The findings of studies from this laboratory are summarized to compare the efficacy of four chemoprotective agents against the effects of cisplatin-induced hearing loss and biochemical damage in the rat cochlea. " 02/20/2007 - "CONCLUSION: The presence of both alleles of 105Val-GSTP1 offered protection against cisplatin-induced hearing impairment. " 01/01/2006 - "In our study hearing loss correlated with the cumulative dose of cisplatin. " 05/01/2003 - "The purpose of this study was to compare the validity of distortion product otoacoustic emissions (DPOAEs) with pure tone audiometry (PTA) in assessing hearing loss in children under cisplatin therapy. " 09/01/2000 - "Two groups of patients were analyzed in this study: group H, 20 patients early and highly sensitive to the ototoxicity of cisplatin; and group N, 19 patients with no hearing impairment under comparable doses of the drug. " Order ALL the reference details at left...
3.	Glycerol (Glycerine)FDA LinkGeneric 03/01/1977 - "The glycerol test also has been reported as being effective for the same purpose but only in Meniere patients with fluctuating hearing loss (Klockhoff & Lindblom, 1966). " 07/01/2000 - "Her left hearing loss was improved during the glycerol test. " 09/01/2005 - "There was no difference in the degree of hearing loss induced by saline or by fluids with viscosities up to 1,000 times greater than that of water (glycerol). " 09/01/2005 - "METHODS: To evaluate the contribution of each of these factors to hearing loss, various volumes of saline, whole blood, or glycerol were applied to the open middle ear cavity of guinea pigs for short periods of time and auditory function was evaluated by recording the threshold of auditory nerve-brainstem evoked responses. " 01/01/2002 - "The glycerol test was positive only in 4 patients with unilateral MD and moderate hearing loss. " Order ALL the reference details at left...
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/1999 - "CONCLUSIONS: Overall injection of intratympanic corticosteroids for the treatment of hearing loss in inner ear disorders appears to be both safe and highly effective for certain disorders. " 07/01/2009 - "The efficacy of adjuvant corticosteroids varied between high- and low-income countries suggesting greater mortality reduction in high-income countries (RR 0.74, 95% CI 0.52-1.05) than in low-income countries (RR 0.87, 95% CI 0.72-1.05) and a beneficial effect on severe hearing loss in high-income countries (RR 0.32, 95% CI 0.18-0.57), whereas, sparse data in low-income countries (RR 1.04, 95% CI 0.66-1.63). " 09/01/1993 - "However, corticosteroids significantly reduced the frequency of bilateral, moderate, or greater hearing loss. " 11/01/1980 - "Topical ocular corticosteroids can usually control IK, and a short trial of systemic corticosteroids is warranted as soon as possible after the onset of hearing loss. " 06/01/2009 - "Early recognition and treatment of otological involvement in CSS is extremely important because of the dramatic response to corticosteroids which may prevent progression of hearing loss." Order ALL the reference details at left...
5.	SteroidsIBA 01/01/1998 - "The evaluation of efficacy of various treatment demonstrates a slight improvement of the hearing loss using steroids associated to vasodilatators, even if no significant difference is found between the different therapies. " 11/01/1995 - "Until recently the site of the lesion has been debatable and the efficacy of steroids commonly prescribed for this type of hearing loss has been said to be doubtful. " 02/01/1994 - "Hearing impairment in 35 cases (55%) was cured or improved by medical treatment including steroids. " 08/01/2010 - "He was treated with a combined regimen of steroids and an antiviral drug, but his profound hearing loss did not resolve. " 01/01/2009 - "Otolaryngologists are more likely to treat with steroids beyond one week of onset of hearing loss whereas general practitioners overwhelmingly will only treat within the first week. " Order ALL the reference details at left...
6.	Gentamicins (Gentamicin)FDA LinkGeneric 02/01/2007 - "The amount of postprocedure hearing loss was significantly greater in the gentamicin group (p = 0.03). " 02/01/2004 - "The amount of postprocedure hearing loss was significantly greater in the gentamicin treatment group (P =.006). " 01/01/2004 - "After the withdrawol of gentamicin, the vestibular pathologic symptoms but not the hearing loss had improved, docummented by the persistance of the audiometric decay in the acute frequencies. " 11/01/2007 - "OBJECTIVE: To study the protective effect of local gene therapy with adeno-associated virus (AAV)-mediated neurotrophin-3 (NT-3) on the function and morphology of the cochlea of guinea pigs with gentamicin-induced hearing loss. " 11/01/2005 - "In this study, we shed light on the mechanisms underlying gentamicin-induced hearing loss. " Order ALL the reference details at left...
7.	Prednisolone (Predate)FDA LinkGeneric 08/27/1993 - "Under high-dosage glucocorticoid treatment (initially 1,000 mg/d prednisolone intravenously for 3 days, then 100 mg/d orally in decreasing doses down to 10 mg daily) the ocular signs improved, but the bilateral hearing impairment persisted. " 06/01/2009 - "Early use of prednisolone can prevent hearing loss and can also be useful in treating the other vasculitic manifestations." 12/01/2000 - "This combination therapy enabled the successful tapering of prednisolone without recurrence of hearing loss. " 11/01/2000 - "Previously we have shown that hearing loss in these mice is reversed with prednisolone treatment. " 01/01/1998 - "A different set of results was obtained from patients with a hearing loss who were treated either with prednisolone or placebo. " Order ALL the reference details at left...
8.	AntioxidantsIBA 06/01/2009 - "Antioxidants administered before sound exposure show promise in mitigating hearing loss in industrial and combat situations. " 10/01/2007 - "The objective of this paper is to highlight some of the important studies published over the past several years that have further contributed to our understanding of the mechanism of antioxidants in attenuating hearing loss. " 10/01/2007 - "SUMMARY: This review elucidates the role of antioxidants in hearing loss and illustrates the continued evolution of research efforts in this field." 10/01/2007 - "PURPOSE OF REVIEW: The role of antioxidants in the management of hearing loss has generated considerable interest over the past several years. " 04/01/2007 - "Consequently, antioxidants protect against aminoglycoside-induced hearing loss in animals and, importantly, they do so without compromising drug serum levels or antibacterial efficacy. " Order ALL the reference details at left...
9.	Methotrexate (Mexate)FDA LinkGeneric 08/01/2000 - "To assess the efficacy of low-dose methotrexate (MTX) given long-term for the treatment of autoimmune hearing loss, we performed a prospective open-label study of 11 patients with treatment-refractory autoimmune hearing loss. " 04/01/2001 - "OBJECTIVE: To assess the efficacy of low-dose methotrexate (MTX) administered for the treatment of autoimmune hearing loss. " 10/08/2003 - "Of the individuals who reached study end points, 24 (80%) of 30 end points were because of measured hearing loss in the methotrexate group and 29 (93.5%) of 31 end points were because of measured hearing loss in the placebo group (P =.15). " 04/01/2001 - "Open trial of methotrexate as treatment for autoimmune hearing loss." 10/01/2004 - "Methotrexate, which initially showed promise, has recently been shown to be ineffective in preventing progression of hearing loss. " Order ALL the reference details at left...
10.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/01/2001 - "However, after performing high-dose cyclophosphamide (CY) therapy, a significant improvement in the hearing loss (more than 10 dB) was observed. " 12/01/2000 - "The first case, a woman of 44, suffered profound hearing loss which was remarkably improved by steroid and cyclophosphamide treatment for a time, and which seemed to be caused by invasion from granulation tissue filled in the tympanic cavity. " 06/01/2007 - "We report a 72-year-old male patient with polyarteritis nodosa treated continuously for 5 years with aggressive immunosuppressive drugs, including cyclophosphamide, who experienced three episodes of acute hearing loss during treatment. " 05/01/1986 - "Treatment with prednisone and cyclophosphamide did not improve the hearing loss. " 12/01/1992 - "One patient, who had received full-dose chemotherapy despite a creatinine clearance of 56 ml/min, developed significant toxicity consisting of transient cyclophosphamide-associated pancarditis, reversible neurotoxicity and partially reversible hearing loss and renal function impairment. " Order ALL the reference details at left...

Therapies and Procedures

1.	Hearing Aids (Hearing Aid) 10/01/2004 - "Though traditional hearing aids remain the mainstay of treatment for most uncorrectable hearing loss, partially implantable devices may offer solutions when standard therapy fails." 08/01/2007 - "CONCLUSION: According to previous studies on the matter, our data suggest that identification of hearing loss at early age associated with early hearing aid fitting, and enrollment in early intervention within the first 12 months of age, may help to obtain good results in the receptive language skills performance. " 02/01/2001 - "Findings were consistent with previous studies showing positive outcomes for newer technologies but also showed that two subjective factors, prefitting hearing aid expectations and acceptance of hearing loss, significantly influenced hearing aid outcome." 03/01/1979 - "This study sought to determine if a high-pass hearing aid can provide increased improvement in word recognition and consonant discrimination over that of a conventional high frequency emphasis hearing aid in listeners with hearing loss limited to frequencies above 1 000 Hz. Word and consonant discrimination were assessed in quiet and in the presence of 12 talker speech babble for 10 subjects under three listening conditions: (1) unaided; (2) wearing a conventional high frequency emphasis hearing aid, and (3) wearing an experimental high-pass instrument. " 04/01/2008 - "CONCLUSIONS: The use of a hearing aid is beneficial for Cantonese tone perception in children who have moderate to severe hearing impairment. " Order ALL the reference details at left...
2.	Cochlear Implants (Cochlear Implant) 01/01/2007 - "These findings suggest that cochlear implants offer some significant benefits to children with hearing impairment in terms of prosody and voice outcomes." 12/01/2009 - "Using acoustic simulations of a cochlear implant and hearing loss, it is shown that localization performance can be improved by up to 14 degrees rms error relative to 48 degrees rms error for broadband noise by artificially introducing ILD cues in the low frequencies. " 09/01/2009 - "There is no doubt that cochlear implants have improved the spoken language abilities of children with hearing loss, but delays persist. " 12/01/2008 - "These deficits in the coding of harmonic sounds may underlie some of the difficulties experienced by people with hearing loss and cochlear implants, and may point to future areas where sound representation in auditory prostheses could be improved." 11/01/2003 - "OBJECTIVE: To evaluate the efficacy of cochlear implants in human immunodeficiency virus-infected individuals and correlate these results with a proposed pathophysiological mechanism of human immunodeficiency virus-associated hearing loss. " Order ALL the reference details at left...
3.	Cochlear Implantation 06/01/2007 - "The identification of two novel pathogenic TMPRSS3 mutations (c.646C-->T - R216C; c.916G-->A - A306T) is described in four affected siblings of German origin with postlingual hearing loss, treated by bilateral cochlear implantation with good results. " 04/01/2003 - "Overall, the results are encouraging and demonstrate that the elderly population with profound hearing loss obtain significant benefits from cochlear implantation despite the age-related auditory processing problems." 05/01/2008 - "CONCLUSIONS: This study found an improvement in quality of life and a favorable cost-utility associated with bilateral cochlear implantation in patients with profound hearing loss. " 11/01/2009 - "This study was undertaken to assess the speech perception benefits, 24 months after cochlear implantation (CI), in 20 young people (age at CI, 8-18.5 years) with prelingual profound hearing loss, in addition to the use of a proposed CI candidacy assessment profile. " 11/01/2009 - "OBJECTIVES: The purpose of this study was to design an animal model of cochlear implantation with an intracochlear fluid delivery system to demonstrate the stability of the device and study the patterns of hearing loss. " Order ALL the reference details at left...
4.	Aftercare (After-Treatment) 10/01/2001 - "Only one patient suffered a significant hearing loss and, most importantly, in all but one patient vestibular function was improved or normalized after treatment. " 01/01/1996 - "Improvement of hearing loss after treatment was generally less effective in the cases with rapidly progressed IBSH than in the cases with SD. " 06/01/1993 - "Improvement of hearing loss after treatment was generally less effective in the cases with rapidly progressed IBSH than in the cases with S.D. " 12/01/2009 - "10 ears suffered from a profound hearing loss and none of them improved after treatment regardless otic capsule affected structures. " 06/01/1984 - "In two patients this hearing-loss improved after treatment and a syphilitic etiology seems plausible. " Order ALL the reference details at left...
5.	Drug Therapy (Chemotherapy) 12/01/2002 - "In contrast, very little information is available about the efficacy of intravenous drug therapy for ISSNHL with the beginning of treatment later than four weeks after the onset of hearing loss. " 09/01/2009 - "The criteria described in this study were inadequate to identify hearing loss following chemotherapy, requiring additional information for physicians to better understand the hearing losses and their implications for the quality of life of patients." 10/01/2009 - "RESULTS: The mean hearing thresholds in both ears showed an elevation (that is a decline) post chemotherapy treatment at 6 and 8kHz of between 20 and 30dB, which is graded as a mild hearing impairment at the higher frequency range. " 09/01/2009 - "METHOD: Hearing loss was classified in 31 patients before and after chemotherapy, according to different criteria, assessing the sensitivity and specificity of each classification system. " 11/01/2008 - "QOL, except for symptoms of sensory neuropathy and hearing loss, in those treated with chemotherapy returned to baseline by 9 months. " Order ALL the reference details at left...

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