Retrospective Investigation of Cutaneous Squamous Cell Carcinoma on the Lip Treated with Peplomycin Administered Through a Superficial Temporal Artery.

Abstract

BACKGROUND:

Continuous intra-arterial (IA) administration of peplomycin (PEP) through a tumor-feeding artery is one of the most effective treatments for cutaneous squamous cell carcinoma (cSCC) in cosmetic areas.

PATIENTS AND METHODS:

In order to determine the effective and safe dose of PEP and the curative rate of IA-PEP, we retrospectively investigated a case series of 24 patients with cSCC on the lips who were treated with IA-PEP.

RESULTS:

IA-PEP reduced the tumor mass in all 24 cases (100%). A complete response occurred in 17 patients (70.8%), and a partial response occurred in seven (29.2%). Moreover, 17 patients (70.8%) were cured, three patients developed cervical lymph node metastasis (12.5%), and four developed local recurrence (16.7%). Three out of the 24 patients developed interstitial pneumonia (12.5%).

CONCLUSION:

Low-dose IA-PEP administered through a superficial temporal artery was a highly effective treatment that achieved a curative response for 70.8% of patients with cSCC on the lips.

• Authors: Taku Fujimura, Kazuhiro Takahashi, Yumi Kambayashi, Sadanori Furudate, Takanori Hidaka, Aya Kakizaki, Akiko Watabe, Takahiro Haga, Akira Hashimoto, Setsuya Aiba
• Journal: Anticancer research (Anticancer Res) Vol. 37 Issue 4 Pg. 1885-1889 (04 2017) ISSN: 1791-7530 [Electronic] Greece
• PMID: 28373456 (Publication Type: Journal Article)
• Copyright: Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Antibiotics, Antineoplastic
• Peplomycin

Topics

• Aged
• Aged, 80 and over
• Antibiotics, Antineoplastic (administration & dosage)
• Carcinoma, Squamous Cell (drug therapy, pathology)
• Female
• Humans
• Infusions, Intra-Arterial
• Lip Neoplasms (drug therapy, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Peplomycin (administration & dosage)
• Prognosis
• Retrospective Studies
• Skin Neoplasms (drug therapy, pathology)
• Temporal Arteries