Effects of Roux-en-Y gastric bypass on insulin secretion and sensitivity, glucose homeostasis, and diabetic control: A prospective cohort study in Chinese patients.

Abstract

BACKGROUND:

To report on the effects of Roux-en-Y gastric bypass operation for obesity on measures of adiposity, insulin secretion and sensitivity, glucose homeostasis, and improvement in diabetic control in Chinese patients.

METHODS:

This was a prospective cohort study of 152 participants (81% with diabetes) who were recruited for bariatric operation.

RESULTS:

Mean body mass index was decreased by 18.1% from 30.31 ± 5.38 kg/m2 at baseline to 24.45 ± 3.79 kg/m2 at 2 years (P < .001). Indices of insulin secretion, including serum c-peptide (both fasted and at various time points during an oral glucose tolerance test) improved at the 3-year follow-up, with a significant improvement in insulin sensitivity and glucose homeostasis.

CONCLUSION:

The effects of Roux-en-Y gastric bypass 3 years postoperative on adiposity were paralleled by a significant improvement in insulin secretion and sensitivity, and glucose tolerance.

• Authors: Mohsen Mazidi, Hong-Kai Gao, Liang Li, Han Hui, Zhang Ye
• Journal: Surgery (Surgery) Vol. 161 Issue 5 Pg. 1423-1429 (05 2017) ISSN: 1532-7361 [Electronic] United States
• PMID: 28236446 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2016. Published by Elsevier Inc.

Chemical References

• Blood Glucose

Topics

• Adiposity
• Asian People
• Blood Glucose
• China
• Diabetes Mellitus, Type 2 (complications, metabolism)
• Female
• Gastric Bypass
• Humans
• Insulin Resistance
• Male
• Middle Aged
• Obesity, Morbid (ethnology, metabolism, surgery)
• Prospective Studies