Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome.

Abstract

Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22.6±0.7 vs. 37.7±3.0kg/m2, respectively) was collected in the fasting state at 0, 24, 48, and 72h during each of four separate interventions in a clinical trial. At baseline, plasma sORP was 12.4% higher (P=0.007), while cORP values were less than half (41.1%, P=0.001) in those with MetS compared with healthy participants. An sORP >140mV detected MetS with 90% sensitivity and 80% specificity, while a cORP <0.50μC detected MetS with 80% sensitivity and 100% specificity. sORP and cORP values in participants with MetS compared with healthy adults were linked to differences in waist circumference and BMI; in plasma markers of dyslipidemia (triglycerides, HDL-cholesterol, and oxidized LDL-cholesterol) and inflammation (C-reactive protein, IL-10); as well as with urinary markers of lipid peroxidation (e.g., 2,3-dinor-5,6-dihydro-8-iso-PGF2α; 2,3-dinor-8-iso-PGF2α). Higher sORP values are a robust indicator of metabolic stress, while lower cORP values act as an indicator of decreased metabolic resilience.

• Authors: Gerd Bobe, Tora J Cobb, Scott W Leonard, Savinda Aponso, Christopher B Bahro, Dipankar Koley, Eunice Mah, Richard S Bruno, Maret G Traber
• Journal: Redox biology (Redox Biol) Vol. 12 Pg. 121-128 (08 2017) ISSN: 2213-2317 [Electronic] Netherlands
• PMID: 28222379 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017. Published by Elsevier B.V.

Chemical References

• Biomarkers
• Cholesterol, HDL
• IL10 protein, human
• Lipoproteins, LDL
• Triglycerides
• Interleukin-10
• C-Reactive Protein

Topics

• Adult
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Cholesterol, HDL (blood)
• Cross-Over Studies
• Double-Blind Method
• Female
• Humans
• Interleukin-10 (blood)
• Lipoproteins, LDL (blood)
• Male
• Metabolic Syndrome (blood)
• Oxidation-Reduction
• Triglycerides (blood)
• Young Adult