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S- (2- (N,N- diisopropylamino)ethyl)isothiourea

structure in first source

Also Known As:

DINOR

Networked: 26 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - Dimaprit: 54
        S-(2-(N,N-diisopropylamino)ethyl)isothiourea: 26
- Sulfur Compounds: 278
  - Thiourea: 362
    - Dimaprit: 54
      - S-(2-(N,N-diisopropylamino)ethyl)isothiourea: 26

Experts

1.	Aponso, Savinda: 1 article (01/2017)
2.	Bahro, Christopher B: 1 article (01/2017)
3.	Bobe, Gerd: 1 article (01/2017)
4.	Bruno, Richard S: 1 article (01/2017)
5.	Cobb, Tora J: 1 article (01/2017)
6.	Koley, Dipankar: 1 article (01/2017)
7.	Leonard, Scott W: 1 article (01/2017)
8.	Mah, Eunice: 1 article (01/2017)
9.	Traber, Maret G: 1 article (01/2017)
10.	Base, Karel: 1 article (01/2012)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 05/28/1992 - "Cell survival studies showed highest toxicity in the constitutively pigmented human melanoma cell line MM418, DINOR being the most effective agent. " 07/05/1994 - "In pigmented melanoma cells (MM418), incorporation of [125I]thiouracil, a false precursor of melanin, increased during the first 24 hr of treatment with DINOR whereas a group 2 drug (R = phenyl) inhibited incorporation of [125I]thiouracil. " 05/28/1992 - "Human melanoma cells were treated in culture with the histamine (H2) agonist S-(3-(N-N-dimethylamino)propyl)isothiourea (dimaprit), a partial agonist, S-(2-(N,N-dimethylamino)ethyl)-isothiourea (nordimaprit), and two analogues of nordimaprit, S-(2-(N,N-diethylamino)ethyl)isothiourea (DENOR) and S-(2-(N,N-diisopropylamino)ethyl)isothiourea (DINOR), to investigate the effects on toxicity and tyrosinase activity. "
2.	Thrombosis (Thrombus) 10/01/2007 - "This trial evaluated the effect of antioxidant supplementation on the urinary excretion of 11-dehydro TXB(2)/2,3 dinor 6 keto PGF(1alpha) ratio, a marker of the pathogenesis of thrombosis and arteriosclerosis. "
3.	Polyneuropathies (Polyneuropathy) 07/01/2006 - "The objective of this study was to establish if diabetes in the presence of polyneuropathy (PN) and/or cardiovascular autonomic neuropathy (CAN) is associated with alterations in the amounts of 8-epi-PGF2alpha (IP) and its metabolites including 2, 3-dinor-8-epi-PGF2alpha (dinor-IP) and 2, 3-dinor-5, 6 dihydro-8-epi-PGF2alpha (dinor-dihydro-IP) in urine. "
4.	Hypercholesterolemia 07/13/1995 - "The aim of this study was to assess the effects of fluvastatin and pravastatin on lipid profiles and urinary thromboxane (TX) A2 metabolites (11-dehydro TXB2 and 2,3-dinor TXB2) in patients with type IIa hypercholesterolemia. "
5.	Arteriosclerosis 10/01/2007 - "This trial evaluated the effect of antioxidant supplementation on the urinary excretion of 11-dehydro TXB(2)/2,3 dinor 6 keto PGF(1alpha) ratio, a marker of the pathogenesis of thrombosis and arteriosclerosis. "

Related Drugs and Biologics

1.	Prostaglandins F
2.	Thromboxanes
3.	8-epi-prostaglandin F2alpha
4.	Pravastatin (Pravachol)
5.	Lipids
6.	Antioxidants
7.	Fluvastatin
8.	Thromboxane A2 (A2, Thromboxane)
9.	Epoprostenol (Prostacyclin)
10.	Thromboxane B2