Abstract | Context:
Obesity, insulin resistance (IR), and diabetes are increasing in youth, especially in girls. IR is associated with muscle mitochondrial dysfunction in youth and adults with diabetes. However, it is unknown whether this relationship is present in youth prior to development of diabetes. Objective: Assess IR and mitochondrial function, including sex differences, in nondiabetic youth. Design: Setting: Academic medical university. Participants: Two hundred seventy-five youth, 13 to 19 years old [43% males: 17.1 (16.52, 17.63) years, body mass index z-score (BMI-Z) 0.36, 64.7% Tanner 5; 57% females: 17.2 (16.43, 17.67) years, BMI-Z 0.72, 78.9% Tanner 5]. Interventions: Fasting laboratories, oral glucose tolerance test, and 31P magnetic resonance spectroscopy. Main Outcome Measures: Results: Compared with males, females were more insulin resistant, with higher triglyceride:HDL ratio [1.95 (1.30, 2.79) vs 1.69 (1.21, 2.23), P = 0.042], HOMA-IR [3.18 (2.42, 4.39) vs 2.76 (2.02, 4.08), P = 0.035], and fasting free fatty acids (FFAs) and lower Matsuda score [3.98 (2.71, 5.96) vs 5.39 (3.43, 7.57), P < 0.001]. After adjustment for the higher BMI and Tanner stage and lower physical activity levels seen in females, there were no sex differences in mitochondrial function nor in any IR measure except FFAs. We did not find an association between measures of IR and mitochondrial function. Conclusions: The greater IR seen in adolescent girls vs boys is mostly explained by differences in BMI and physical activity. Mitochondrial function does not appear to be related to IR in a large cohort of nondiabetic youth.
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Authors | Melanie Cree-Green, Ninghe Cai, Laura Pyle, Brandy Ringham, Mark S Brown, Bradley R Newcomer, Kristen J Nadeau, Dana Dabelea |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 102
Issue 5
Pg. 1652-1660
(05 01 2017)
ISSN: 1945-7197 [Electronic] United States |
PMID | 28204552
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Endocrine Society |
Chemical References |
- Fatty Acids, Nonesterified
- Lipoproteins, HDL
- Phosphorus Isotopes
- Triglycerides
- Adenosine Diphosphate
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Topics |
- Adenosine Diphosphate
(metabolism)
- Adolescent
- Cohort Studies
- Cross-Sectional Studies
- Exercise
(physiology)
- Fatty Acids, Nonesterified
(metabolism)
- Female
- Glucose Tolerance Test
- Humans
- Insulin Resistance
- Lipoproteins, HDL
(metabolism)
- Magnetic Resonance Spectroscopy
- Male
- Mitochondria, Muscle
(metabolism)
- Muscle Strength
- Muscle, Skeletal
(metabolism)
- Oxidative Phosphorylation
- Phosphorus Isotopes
- Sex Factors
- Triglycerides
(metabolism)
- Young Adult
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