Myocardial infarction due to
ischemia accounts for majority of deaths among cardiovascular disorders.
Isoproterenol (ISO) induced
myocardial infarction and the protection offered by
piperine was investigated in the present report.
Lipid profile analysis by determining the levels of
cholesterol,
phospholipids,
triglycerides and
lipoproteins in serum and heart tissues showed anti-dyslipidemic action of
piperine against ISO induced myocardial injury by modulating the ISO induced altered
lipid profiles, maintaining to near control values. ISO treatment increased
TBARS levels, PCC,
serum markers of heart, depleted
antioxidant status (GSH, SOD, CAT, GPx and GST) in tissues and, total,
protein- and non-
protein-sulfhydryl levels in serum and heart tissues.
Piperine pre-treatment decreased the levels of
serum markers, lipid peroxidation and PCC with increased
antioxidant status in the heart tissues of ISO administered rats. Increased levels of the
glycoprotein components in serum and decreased levels in heart tissues upon ISO administration were restored to near normal levels by
piperine pre-treatment. Our present reports also showed the modulatory effect of
piperine on membrane bound
ATPase's showing protection against ISO induced changes in membrane fluidity. The present study proved
piperine as a potent therapeutic agent with its
antioxidant and anti-dyslipidemic action against ISO induced
myocardial infarction.