Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation.

Abstract

BACKGROUND:

The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions.

METHODS:

PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score.

RESULTS:

DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found.

CONCLUSIONS:

STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons. © 2016 International Parkinson and Movement Disorder Society.

• Authors: Gian D Pal, Bichun Ouyang, Geidy Serrano, Holly A Shill, Christopher Goetz, Glenn Stebbins, Leo Verhagen Metman, Erika Driver-Dunckley, Shyamal H Mehta, John N Caviness, Marwan N Sabbagh, Charles H Adler, Thomas G Beach, Arizona Study of Aging Neurodegenerative Disorders
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 32 Issue 2 Pg. 274-277 (02 2017) ISSN: 1531-8257 [Electronic] United States
• PMID: 27911008 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: © 2016 International Parkinson and Movement Disorder Society.

Chemical References

• alpha-Synuclein

Topics

• Aged
• Aged, 80 and over
• Deep Brain Stimulation
• Female
• Humans
• Locus Coeruleus (metabolism, pathology)
• Male
• Olfactory Bulb (metabolism, pathology)
• Parkinson Disease (metabolism, pathology, therapy)
• Substantia Nigra (metabolism, pathology)
• Subthalamic Nucleus
• alpha-Synuclein (metabolism)