Abstract | BACKGROUND: OBJECTIVE: To assess the prognostic value of FLC in OCB-positive patients with clinically isolated syndrome (CIS) suggestive of MS and early MS. METHODS: We determined FLC kappa (KFLC) and lambda (LFLC) in CSF and serum by nephelometry in 61 patients (CIS ( n = 48), relapsing-remitting multiple sclerosis ( n = 13)) and 60 non-inflammatory neurological controls. Median clinical follow-up time in CIS was 4.8 years (interquartile range (IQR), 1.5-6.5 years). Patients underwent 3T magnetic resonance imaging (MRI) at baseline and follow-up (median time interval, 2.2 years; IQR, 1.0-3.7 years) to determine T2 lesion load (T2LL) and percent brain volume change (PBVC). RESULTS: CSF FLC were significantly increased in CIS/MS compared to controls (all p < 0.001). A lower KFLC/LFLC CSF ratio was associated with CIS-clinically definite multiple sclerosis (CDMS) conversion (hazard ratio (HR) = 2.89; 95% confidence interval (CI) = 1.17-7.14; p < 0.05). No correlations were found for FLC variables with T2LL or PBVC. CONCLUSION: Our study confirms increased intrathecal synthesis of FLC in CIS/MS which supports their diagnostic contribution. The KFLC/LFLC CSF ratio appears to have a prognostic value in CIS beyond OCB.
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Authors | Margarete M Voortman, Tatjana Stojakovic, Lukas Pirpamer, Margit Jehna, Christian Langkammer, Hubert Scharnagl, Markus Reindl, Stefan Ropele, Thomas Seifert-Held, Juan-Jose Archelos, Siegrid Fuchs, Christian Enzinger, Franz Fazekas, Michael Khalil |
Journal | Multiple sclerosis (Houndmills, Basingstoke, England)
(Mult Scler)
Vol. 23
Issue 11
Pg. 1496-1505
(Oct 2017)
ISSN: 1477-0970 [Electronic] England |
PMID | 27899552
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Immunoglobulin kappa-Chains
- Immunoglobulin lambda-Chains
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Topics |
- Adult
- Biomarkers
(blood, cerebrospinal fluid)
- Female
- Follow-Up Studies
- Humans
- Immunoglobulin kappa-Chains
(blood, cerebrospinal fluid)
- Immunoglobulin lambda-Chains
(blood, cerebrospinal fluid)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Multiple Sclerosis
(blood, cerebrospinal fluid, diagnostic imaging)
- Multiple Sclerosis, Relapsing-Remitting
(blood, cerebrospinal fluid, diagnostic imaging)
- Prognosis
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