Oligoclonal Bands

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555 relevant articles (11 outcomes, 27 trials/studies) found for this Bio-Agent

Description: Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.

Also Known As:

Oligoclonal IgG; Oligoclonal IgM; Bands, Oligoclonal; IgG, Oligoclonal; IgM, Oligoclonal; Immunoglobulins, Oligoclonal; Oligoclonal Immunoglobulins

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58433

Blood Proteins: 3862

Serum Globulins: 74

Immunoglobulins: 20136

Antibodies: 77322

Oligoclonal Bands: 555

Immunoproteins: 30

Immunoglobulins: 20136

Antibodies: 77322

Oligoclonal Bands: 555

Globulins: 305

Serum Globulins: 74

Immunoglobulins: 20136

Antibodies: 77322

Oligoclonal Bands: 555

Biological Factors: 931

Biological Markers: 21607

Oligoclonal Bands: 555

Experts

1.	Itoyama, Y: 3 articles (04/2007 - 12/2002)
2.	Nakashima, I: 3 articles (04/2007 - 12/2002)
3.	Sato, S: 3 articles (04/2007 - 12/2002)
4.	Fujihara, K: 3 articles (04/2007 - 12/2002)
5.	Teelken, A: 2 articles (04/2008 - 07/2007)
6.	Koch, M: 2 articles (04/2008 - 07/2007)
7.	De Keyser, J: 2 articles (04/2008 - 07/2007)
8.	Heersema, D: 2 articles (04/2008 - 07/2007)
9.	Mostert, J: 2 articles (04/2008 - 07/2007)
10.	Rovira, A: 2 articles (03/2008 - 12/2001)

Related Diseases

1.	Multiple Sclerosis 09/15/2000 - "Improved methods for the application of random peptide phage libraries to the study of the oligoclonal bands in cerebrospinal fluid of patients with multiple sclerosis." 01/01/1996 - "A recent study suggested that a significant portion of the oligoclonal IgG found in multiple sclerosis (MS) cerebrospinal fluid may be removed by absorption with simian virus 5 (SV5). " 01/01/1994 - "To evaluate the utility of these formulas in the presence of blood-brain barrier (BBB) damage, we present the results from a study of serum and cerebrospinal fluid (CSF) samples from 125 healthy individuals, 18-88 years of age; 1072 consecutive patients without oligoclonal IgG bands (OCBs) in the CSF, 683 without BBB damage (CSF/S: albumin ratio < 9.8) and 389 with BBB damage (CSF/S albumin ratio 9.8-30); and 106 patients with definite multiple sclerosis (MS). " 01/01/1989 - "During the 6 years to December 1988, 191 patients underwent evoked potential (EP) studies and cerebrospinal fluid (CSF) analysis for oligoclonal bands at the Queen Elizabeth Hospital, for the differential diagnosis of multiple sclerosis (MS). " 12/01/1982 - "Study of the IgG oligoclonal bands in cerebral spinal fluid in multiple sclerosis by electroimmunofixation." Order ALL the reference details at left...
2.	Leukocytosis (Pleocytosis) 02/01/2003 - "This form of MS generally has a higher age at onset and a higher female to male ratio than conventional MS. Opticospinal MS is also characterised by frequent relapses, severe disability, few brain lesions visible on MRI, long lesions extending over many vertebral segments visible on spinal-cord MRI, pleocytosis and an absence of oligoclonal bands in the CSF, and a pronounced shift in the responses of T-helper-1 and T-cytotoxic-1 cells throughout relapse and remission phases. " 08/01/1995 - "CSF study revealed marked elevation of pleocytosis and oligoclonal IgG bands. " 09/01/2008 - "CSF analysis revealed a high protein content, lymphocytic pleocytosis, and oligoclonal IgG bands not present in the serum. " 10/01/2007 - "RESULTS: The cerebrospinal fluid test showed mononuclear pleocytosis with negative oligoclonal bands in both patients. " 07/01/2007 - "Cerebrospinal fluid examination showed a predominantly lymphocytic pleocytosis (64-120x10(6) cells/L) and oligoclonal bands were detected in two cases. " Order ALL the reference details at left...
3.	Measles 05/01/1997 - "Isoelectric focusing showed predominantly measles-specific oligoclonal IgG bands in the CSF. " 06/01/1985 - "Measles specific oligoclonal IgG bands were found in the sera and spinal fluids of these animals. " 11/01/1982 - "The samples showed dark brown measles-specific oligoclonal bands in the alkaline pH region of the gel, whereas the controls showed no significant staining. " 12/01/1979 - "Measles antibody level remained elevated, and oligoclonal IgG was present in both serum and CSF. " 08/01/1977 - "However, the nature of the correlation between occurrence of oligoclonal IgG and high measles antibody titre remains to be explained." Order ALL the reference details at left...
4.	Transverse Myelitis (Necrotizing Myelitis) 09/01/2003 - "CONCLUSION: Idiopathic RTM might be a disease entity distinct from MSRTM, differing in its male preponderance, absence of oligoclonal bands, frequent multiple relapses, and frequent presentation as acute transverse myelitis." 06/01/2009 - "RECENT FINDINGS: Studies of children after a first episode of demyelination have identified disease onset in adolescence, intrathecal oligoclonal bands and optic neuritis as associated with a higher MS risk, whereas prepubertal onset, presence of polyfocal features with encephalopathy, and transverse myelitis have been associated with a lower risk of subsequent MS. The relapsing-remitting form of MS accounts for over 96% of all MS in children. " 03/01/2005 - "Here, we report a case of acute transverse myelitis in a woman developing 4 years after documented HCV seropositivity, associated with intrathecal anti-HCV protein IgG. Isoelectrofocusing of all CSF samples before and after immunoabsorption with recombinant structural HCV proteins revealed disappearance or marked decrease of some oligoclonal IgG bands suggesting binding to HCV proteins. " Order ALL the reference details at left...
5.	Myelitis 08/01/1993 - "GFAP-specific oligoclonal bands in the CSF of a patient with acute myelitis." 08/01/1993 - "The specificity for GFAP (glial fibrillary acidic protein) of oligoclonal IgG bands in the CSF of a patient with acute myelitis was demonstrated by isoelectric focusing and affinity blotting. " 07/01/1990 - "It is recommended that, before the diagnosis of MS is changed to that of HTLV-I-associated chronic myelitis, at least 2 of the following abnormalities be present: (1) clinical or electrophysiologic involvement of peripheral nerve or muscle; (2) the presence of oligoclonal bands in the serum; (3) the presence in blood or CSF of lymphocytes with multilobed nuclei; (4) a positive serologic test for syphilis; (5) the presence of a sicca syndrome; and (6) the presence of pulmonary lymphocytic alveolitis." 06/01/1979 - "oligoclonal bands and/or regional increases of gamma-globulins, were more frequent in patients with (meningo-)encephalitic or (meningo-)-myelitis/radiculitic disorders (respectively 69 and 48%) than in subjects with meningitis or Guillain-Barré syndrome (17%). " 11/01/2007 - "Recurrent NMO has been described as optic-spinal multiple sclerosis (OSMS) in Japan, but it has been known that NMO has distinct clinical and laboratory findings (female preponderance, severe disability, longitudinally extensive myelitis, CSF-pleocytosis, negative oligoclonal IgG bands, etc) from those in typical MS. In addition, anti-aquaporin-4 (AQP4) antibody and loss of AQP4 in the active perivascular NMO lesions with deposition of immunoglobulins and activated complements were recently found to be NMO-specific, strongly suggesting that NMO is a clinical entity that should be separated from MS. In accordance with these unique features of NMO, different therapeutic responses between NMO and MS have been observed, that is, interferon-beta, a disease-modifying therapy (DMT) for MS, is less effective in NMO, while long-term administration of corticosteroid and immunosuppressive agents reduce relapses of NMO. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antibodies
3.	Proteins (Proteins, Gene)
4.	Sepharose (Agarose)
5.	Immunoglobulins (Immunoglobulin)
6.	Immunoglobulin A (IgA)
7.	Cyclophosphamide (Cytoxan)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	Interferon-beta
10.	Immunosuppressive Agents (Immunosuppressants)

Related Therapies and Procedures

1.	Plasmapheresis
2.	Drug Therapy (Chemotherapy)
3.	Thymectomy
4.	Transplantation (Transplant Recipients)

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