The combination of osthole with baicalin protects mice from Staphylococcus aureus pneumonia.

Abstract

We reported the inhibition of α-Hemolysin (Hla) production in methicillin-resistant Staphylococcus aureus USA300 by osthole and further investigated the combination of osthole and baicalin in the treatment of staphylococcal pneumonia. Using cytotoxicity assays and a mouse model of intranasal lung infection, we evaluated the effect of combined therapy. Our results suggest that the combination of osthole and baicalin alleviated S. aureus-mediated A549 cell injury and protected mice from S. aureus pneumonia.

• Authors: Shui Liu, Bowen Liu, Zhao-Qing Luo, Jiaming Qiu, Xuan Zhou, Gen Li, Bing Zhang, Xuming Deng, Zhenguo Yang, Jianfeng Wang
• Journal: World journal of microbiology & biotechnology (World J Microbiol Biotechnol) Vol. 33 Issue 1 Pg. 11 (Jan 2017) ISSN: 1573-0972 [Electronic] Germany
• PMID: 27878749 (Publication Type: Journal Article)

Chemical References

• Bacterial Toxins
• Coumarins
• Flavonoids
• Hemolysin Proteins
• staphylococcal alpha-toxin
• baicalin
• osthol

Topics

• A549 Cells
• Animals
• Bacterial Toxins (antagonists & inhibitors)
• Coumarins (administration & dosage, pharmacology)
• Disease Models, Animal
• Drug Therapy, Combination
• Flavonoids (administration & dosage, pharmacology)
• Gene Expression Regulation, Bacterial (drug effects)
• Hemolysin Proteins (antagonists & inhibitors)
• Humans
• Methicillin-Resistant Staphylococcus aureus (drug effects, enzymology)
• Mice
• Microbial Sensitivity Tests
• Pneumonia, Staphylococcal (prevention & control)