Staphylococcal Pneumonia

Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.

Also Known As:

Pneumonia, Staphylococcal; Staphylococcus Aureus Pneumonia; Pneumonia, Staphylococcus Aureus; Pneumonias, Staphylococcal; Pneumonias, Staphylococcus Aureus; Staphylococcal Pneumonias; Staphylococcus Aureus Pneumonias

Networked: 225 relevant articles (14 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Bacterial Infections (Bacterial Infection)
3.	Pneumonia (Pneumonitis)
4.	Human Influenza (Influenza)
5.	Osteomyelitis

Experts

1.	Deng, Xuming: 8 articles (10/2019 - 11/2011)
2.	Wang, Jianfeng: 8 articles (10/2019 - 11/2011)
3.	Niu, Xiaodi: 7 articles (10/2019 - 11/2011)
4.	Dong, Jing: 7 articles (04/2013 - 11/2011)
5.	Sun, Junfeng: 6 articles (12/2021 - 01/2012)
6.	Natanson, Charles: 6 articles (12/2019 - 07/2003)
7.	Zhang, Yu: 6 articles (04/2013 - 11/2011)
8.	Bubeck Wardenburg, Juliane: 6 articles (01/2010 - 02/2007)
9.	Wang, Xin: 5 articles (02/2022 - 06/2012)
10.	Solomon, Steven B: 5 articles (12/2019 - 01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Staphylococcal Pneumonia:

1.	VaccinesIBA 03/05/2018 - "Protective effects of a nanoemulsion adjuvant vaccine (2C-Staph/NE) administered intranasally against invasive Staphylococcus aureus pneumonia." 02/18/2008 - "Vaccine protection against Staphylococcus aureus pneumonia." 01/01/2023 - "RV methodologies have been successfully applied for the identification of new vaccines against serogroup B meningococcus (MenB), Bacillus anthracis, Streptococcus pneumonia, Staphylococcus aureus, Chlamydia pneumoniae, Porphyromonas gingivalis, Edwardsiella tarda, and Mycobacterium tuberculosis. " 02/18/2008 - "This finding represents the first successful vaccine strategy for the treatment of staphylococcal pneumonia." 04/13/2011 - "An evaluation of the emerging vaccines and immunotherapy against staphylococcal pneumonia in children."
2.	Linezolid (Zyvox)FDA Link 10/01/2010 - "Glicopeptides and linezolid are therapeutic options indicated in the treatment of staphylococcal pneumonia produced either by MRSA strains or pvl positive S. " 11/01/2009 - "Linezolid dosing for staphylococcal pneumonia in children." 05/01/2004 - "In our opinion, the optimization of the length of treatment and the reduction of mortality with linezolid in staphylococcal pneumonia are two major recent developments." 07/01/2023 - "The combination of insulin and linezolid ameliorates Staphylococcus aureus pneumonia in individuals with diabetes via the TLR2/MAPKs/NLRP3 pathway." 05/01/2020 - "Linezolid versus vancomycin cost in the treatment of staphylococcal pneumonia."
3.	Vancomycin FDA LinkGeneric 10/01/2014 - "To analyze serum vancomycin concentration after administration of different therapeutic doses in children with Staphylococcus aureus pneumonia (SAP) in order to determine the appropriate dose of vancomycin in clinical administration. " 10/01/2014 - "[Analysis of serum vancomycin concentration after administration of different doses in children with Staphylococcus aureus pneumonia]." 04/01/2013 - "A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥ 400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin therapeutic monitoring consensus guidelines for treating all serious S. " 10/01/2018 - "Time Course and Extent of Renal Function Changes in Patients Receiving Treatment for Staphylococcal Pneumonias: An Analysis Comparing Telavancin and Vancomycin from the ATTAIN Trials." 05/01/2020 - "Linezolid versus vancomycin cost in the treatment of staphylococcal pneumonia."
4.	MicroRNAs (MicroRNA)IBA 01/24/2020 - "In the present study, we showed that microRNA (miR)-127 played a key role in controlling bacterial infection and conferred a profound protection against staphylococcal pneumonia. "
5.	Hemolysin Proteins (Hemolysins)IBA 08/01/1966 - "I. Anti-alpha hemolysin titer in the sera of rabbits with experimentally induced staphylococcal pneumonia]." 07/01/2009 - "Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia." 01/01/2016 - "Curcumin protects mice from Staphylococcus aureus pneumonia by interfering with the self-assembly process of α-hemolysin." 01/01/2013 - "Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin." 07/15/2012 - "Baicalin protects mice from Staphylococcus aureus pneumonia via inhibition of the cytolytic activity of α-hemolysin."
6.	Penicillins (Penicillin)FDA Link 07/01/1961 - "CAse 502: the management of penicillin resistant staphylococcal pneumonia with dimethoxyphenly penicillin." 11/01/1944 - "Report on a Case of Staphylococcal Pneumonia with Staphylococcal Septicaemia: Treated with Penicillin." 01/01/1984 - "However, as first choice therapy it should be reserved for cases of penicillin allergy, or cases of strongly suspected staphylococcal pneumonia. " 02/26/1977 - "Seven such tolerant strains have been isolated from blood, bone, or sputum of patients who responded poorly to penicillin treatment of endocarditis, osteomyelitis, or staphylococcal pneumonia. " 08/01/1965 - "[Changes in the organs following the use of sulfadimezin, penicillin and erythromycin in staphylococcal pneumonia. "
7.	Gentamicins (Gentamicin)FDA LinkGeneric 01/01/1996 - "[Effectiveness of the treatment of staphylococcal pneumonia with liposomal gentamicin in an experiment]." 12/01/1990 - "We analyzed the general condition of patients, etiology, mortality, prognosis and management and reached to the conclusion that (1) gram-negative bacilli become major pathogen in replace of Gram-positive staphylococcus aureus in 1980s, but staphylococcus aureus pneumonia is still a serious disease (2) the prognosis of the patient is related to underlying disease, nourishment and complication (3) at present, Cephalosporin V is most effective in Gram-positive cocci pneumonia and Gentamycin or Cephalosporin V, in Gram-negative bacilli pneumonia. " 04/01/2002 - "Flucloxacillin or dicloxacillin should be added if staphylococcal pneumonia is suspected, and gentamicin or other specific therapy if gram-negative pneumonia is suspected; a third-generation cephalosporin plus intravenous erythromycin is recommended as initial therapy for severe cases. "
8.	AntigensIBA 06/01/1984 - "[Comparative study of the indices of immunological reactivity and of the HLA antigen system in staphylococcal pneumonia in young children]." 12/01/1982 - "Although the majority of patients did not have detectable free staphylococcal antigen, it was found in three patients with staphylococcal pneumonia. " 02/18/2008 - "Active immunization with a mutant form of Hla (Hla(H35L)), which cannot form pores, generates antigen-specific immunoglobulin G responses and affords protection against staphylococcal pneumonia. "
9.	ceftobiproleIBA 08/01/2009 - "In a murine model of staphylococcal pneumonia, we demonstrated that ceftobiprole penetrated into ELF from the plasma at a median level of nearly 69% (25th to 75th percentile range, 25 to 187%), as indexed to the ratio of values for the area under the concentration-time curve in ELF and plasma. " 08/01/2009 - "Identifying exposure targets for treatment of staphylococcal pneumonia with ceftobiprole." 08/01/2019 - "Clinical cure with ceftriaxone versus ceftaroline or ceftobiprole in the treatment of staphylococcal pneumonia: a systematic review and meta-analysis." 03/01/2017 - "Our results suggest that ceftobiprole is highly active against S. aureus and is an effective alternative to vancomycin or linezolid in the management of staphylococcal pneumonia. "
10.	Intravenous Immunoglobulins (IVIG)FDA Link 10/01/1993 - "Passive local immunotherapy of experimental staphylococcal pneumonia with human intravenous immunoglobulin." 01/01/1995 - "Toxic shock syndrome after staphylococcal pneumonia treated with intravenous immunoglobulin." 10/01/1993 - "The efficacy of IVIG was tested in an experimental model of staphylococcal pneumonia, using both an MRSA clinical isolate and reference strain Cowan III, in mice immunosuppressed with cyclophosphamide. "

Therapies and Procedures

1.	Therapeutics 12/15/2021 - "Anti-PD-L1 Therapy Does Not Improve Survival in a Murine Model of Lethal Staphylococcus aureus Pneumonia." 01/01/2021 - "This meta-analysis has demonstrated that the NAAT can be applied as the preferred initial test for timely diagnosis of staphylococcal pneumonia in LRT samples for successful antimicrobial therapy." 06/01/1980 - "Clinical approach to the choice of antimicrobial therapy, case number 18: staphylococcal pneumonia." 04/01/1974 - "[Effect of modern diagnosis and adequate therapy on the outcome of staphylococcal pneumonia in children]." 09/01/1966 - "[Clinical aspects and therapy of complicated staphylococcal pneumonia in children]."
2.	Intranasal Administration 01/01/2019 - "Efficacy of Intranasal Administration of the Recombinant Endolysin SAL200 in a Lethal Murine Staphylococcus aureus Pneumonia Model."
3.	Artificial Respiration (Mechanical Ventilation) 01/01/2016 - "Mechanical Ventilation Alters the Development of Staphylococcus aureus Pneumonia in Rabbit." 11/01/2009 - "The brain computed tomogram was not remarkable, but Glasgow Coma Scale score remained at 8. Mechanical ventilation was required for rapidly progressive hypoxaemia related to Staphylococcus aureus pneumonia and septicaemia. " 04/01/1991 - "We report a patient with fulminant Staphylococcus aureus pneumonia complicated by chronic BPF formation which prevented weaning from mechanical ventilation due to severe air leak. " 01/01/1981 - "Staphylococcus aureus pneumonia as a complication during treatment of neurosurgical patients with mechanical ventilation." 01/01/1981 - "During 1978 a high incidence of Staphylococcus aureus pneumonia (11/54) was found in patients treated with mechanical hyperventilation for cerebral lesions, compared to other patients on mechanical ventilation in the same ward (1/148). "
4.	Extracorporeal Membrane Oxygenation 05/01/2005 - "PATIENT 2 was a 13-yr-old male treated with venoarterial ECMO for cardiopulmonary failure from necrotizing staphylococcal pneumonia. " 11/01/2010 - "Panton-Valentine leukocidin expressing Staphylococcus aureus pneumonia managed with extracorporeal membrane oxygenation: experience and outcome." 09/09/2021 - "Near-fatal Panton-Valentine leukocidin-positive Staphylococcus aureus pneumonia, shock and complicated extracorporeal membrane oxygenation cannulation: A case report."
5.	Immunotherapy 01/01/2019 - "Immunotherapy With Antiprogrammed Cell Death 1 Antibody Improves Outcome in a Mouse Model of Spinal Cord Injury Followed by Staphylococcus aureus Pneumonia." 04/13/2011 - "An evaluation of the emerging vaccines and immunotherapy against staphylococcal pneumonia in children." 10/01/1993 - "Passive local immunotherapy of experimental staphylococcal pneumonia with human intravenous immunoglobulin."