Abstract | BACKGROUND: METHODS: RESULTS: The GP2a ELISA revealed a significantly higher assay accuracy in contrast to the GP2t assay (sensitivity ≤3 disease days: 91.7%, specificity: 96.7%, positive likelihood ratio [LR+]: 24.6, LR-: 0.09). GP2a and GP2t levels as well as prevalences were significantly elevated in early acute pancreatitis (≤3 disease days) compared to all control cohorts (p<0.05, respectively). GP2a and GP2t levels were significantly higher in patients with severe acute pancreatitis at admission compared with mild cases (p<0.05, respectively). Odds ratio for GP2a regarding mild vs. severe acute pancreatitis with lethal outcome was 7.8 on admission (p=0.0222). GP2a and GP2t levels were significantly correlated with procalcitonin [Spearman's rank coefficient of correlation (ρ)=0.21, 0.26; p=0.0110, 0.0012; respectively] and C-reactive protein (ρ=0.37, 0.40; p<0.0001; respectively). CONCLUSIONS:
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Authors | Dirk Roggenbuck, Alexander Goihl, Katja Hanack, Pamela Holzlöhner, Christian Hentschel, Miklos Veiczi, Peter Schierack, Dirk Reinhold, Hans-Ulrich Schulz |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 55
Issue 6
Pg. 854-864
(May 01 2017)
ISSN: 1437-4331 [Electronic] Germany |
PMID | 27837595
(Publication Type: Journal Article)
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Chemical References |
- GP2 protein, human
- GPI-Linked Proteins
- Protein Isoforms
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Topics |
- Acute Disease
- Adult
- Aged
- Blood Chemical Analysis
- Case-Control Studies
- Cohort Studies
- Female
- GPI-Linked Proteins
(blood)
- Humans
- Male
- Middle Aged
- Pancreatitis
(blood, diagnosis)
- Prognosis
- Protein Isoforms
(blood)
- Serologic Tests
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