Coexisting neuronal autoantibodies among children with demyelinating syndromes.

Abstract

OBJECTIVES:

To determine the incidence and clinical relevance of neuronal autoantibodies in children with demyelinating syndromes.

METHODS:

We conducted a prospective study including 31 consecutive children with demyelinating syndromes. Four patients with N-Methyl-D-aspartate receptor (NMDAR) encephalitis, 32 patients with Guillain-Barre syndrome, 13 children with benign childhood epilepsy, and 28 healthy children were used as controls. Prior to initiating immunomodulatory therapy, serum samples were tested for antibodies against NMDAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) 1, AMPAR2, leucine-rich glioma-activated protein 1, contactin-associated protein 2, gamma-aminobutyric acid B receptors, paraneoplastic ma antigen 2 (PNMA2/Ta), Yo, Ri, Hu, CV2, amphiphysin, and aquaporin-4 by indirect immunofluorescence assays.

RESULTS:

Three anti-neuronal antibodies were detected; NMDAR antibody in one with multiple sclerosis, PNMA2/Ta antibody in one with multiple sclerosis, and Yo antibody in one with clinically isolated syndrome. The positivity rate of neuronal autoantibodies in demyelinating syndrome was 10%. All seropositive patients were found to be negative for tumor screening. None of these patients exhibited symptoms of encephalitis.

CONCLUSION:

Children with demyelinating syndromes without symptoms of encephalitis can be positive for anti-neuronal antibodies.

• Authors: Hikmet Kıztanır, Gonca Bektaş, Edibe Pembegül Yıldız, Tuğçe Aksu Uzunhan, Burak Tatlı, Nur Aydınlı, Mine Çalışkan, Meral Özmen
• Journal: Brain & development (Brain Dev) Vol. 39 Issue 3 Pg. 248-251 (Mar 2017) ISSN: 1872-7131 [Electronic] Netherlands
• PMID: 27823947 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• Nerve Tissue Proteins
• Receptors, N-Methyl-D-Aspartate
• amphiphysin

Topics

• Adolescent
• Autoantibodies (blood, immunology)
• Child
• Child, Preschool
• Demyelinating Diseases (blood, diagnosis, immunology)
• Encephalitis (blood, complications, immunology)
• Epilepsy (blood, complications, diagnosis)
• Female
• Humans
• Male
• Nerve Tissue Proteins (immunology)
• Prospective Studies
• Receptors, N-Methyl-D-Aspartate (immunology)