HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

gamma-Aminobutyric Acid (GABA)

Subscribe to New Research on gamma-Aminobutyric Acid

The most common inhibitory neurotransmitter in the central nervous system.

Also Known As:

GABA; 4-Aminobutanoic Acid; Aminalon; Aminalone; Gammalon; Lithium GABA; gamma-Aminobutyric Acid, Calcium Salt (2:1); gamma-Aminobutyric Acid, Hydrochloride; gamma-Aminobutyric Acid, Monolithium Salt; gamma-Aminobutyric Acid, Monosodium Salt; gamma-Aminobutyric Acid, Zinc Salt (2:1); 4 Aminobutanoic Acid; 4 Aminobutyric Acid; Acid, Hydrochloride gamma-Aminobutyric; GABA, Lithium; Hydrochloride gamma-Aminobutyric Acid; gamma Aminobutyric Acid; gamma Aminobutyric Acid, Hydrochloride; gamma Aminobutyric Acid, Monolithium Salt; gamma Aminobutyric Acid, Monosodium Salt; 4-Aminobutyric Acid; Butanoic acid, 4-amino-

Networked: 4958 relevant articles (158 outcomes, 552 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lewis, David A: 23 articles (12/2009 - 10/2002)
2.	Snead, O Carter: 13 articles (11/2009 - 01/2003)
3.	Gibson, K Michael: 13 articles (03/2009 - 01/2003)
4.	Ben-Ari, Yehezkel: 12 articles (08/2009 - 11/2003)
5.	Hashimoto, Takanori: 12 articles (06/2009 - 07/2003)
6.	Krystal, John H: 11 articles (08/2008 - 03/2004)
7.	Won, Moo Ho: 11 articles (11/2007 - 07/2002)
8.	Benes, Francine M: 10 articles (02/2010 - 06/2002)
9.	Rothman, Douglas L: 10 articles (08/2006 - 11/2002)
10.	Hwang, In Koo: 9 articles (10/2009 - 12/2002)

Related Diseases

1.	Seizures (Seizure) 02/01/2008 - "Enhanced GABA activity resulted in a significant reduction of seizure duration. " 09/01/1990 - "There was significantly greater sensitivity to GABA in stimulated El mice (which had 14-18 convulsions induced at weekly intervals) than in unstimulated El mice (which had not experienced convulsions) or ddY mice. " 02/01/1986 - "These results are consistent with the concept that drugs which facilitate GABAergic transmission are effective against seizures related to an impairment of GABA transmission. " 06/04/1987 - "These results further support the hypothesis that elevation of cerebral GABA levels is protective against a range of experimentally induced seizures, particularly when the substantia nigra is the target of such manipulations." 01/01/2003 - "A side difference in brain GABA+/Cr signal between the epileptogenic and non-epileptogenic hemisphere before VGB treatment correlates with an improved seizure control under VGB treatment regardless whether the measurement is done focus-near or focus-distant." Order ALL the reference details at left...
2.	Epilepsy (Aura) 02/01/1993 - "Previous studies have shown significantly greater GABA levels and numbers of GABAergic neurons in the central nucleus of the inferior colliculus (ICCN) of genetically epilepsy-prone rats (GEPR-9s). " 05/01/2004 - "CONCLUSIONS: It is suggested that subacute electrical stimulation of PHC is more effective in patients with less severe epilepsy, an effect associated with a high GABA tissue content and a low rate of cell loss." 01/01/1991 - "In recent years considerable emphasis has been placed on the hypothesis that enhancement of GABA transmission could be beneficial in some types of epilepsy. " 07/01/1986 - "The iontophoretic dose (current) of GABA required to suppress neuronal firing in the epilepsy-prone rat was significantly greater than that required in neurons of the normal rat. " 10/01/1996 - "Drugs which increase the amount of GABA available in presynaptic endings might thus be useful in the treatment of these therapeutically complicated forms of epilepsy. " Order ALL the reference details at left...
3.	Pain (Aches) 10/09/2009 - "Equally importantly, the GABA concentration in the spinal cord increased significantly after GAD65 introduction, and pain symptoms were dramatically reduced and persistently controlled. " 10/01/2005 - "Although the role of T and GABA(A) currents in pathophysiology of neuropathic pain (NPP) is not established, it appears that blockade of T currents and/or potentiation of GABA(A) currents could be beneficial in the management of NPP. " 03/01/2009 - "The results are in line with animal findings on the role of GABA in pain processing and with studies in humans showing analgesic efficacy of GABA-related drugs in clinical pain conditions." 05/03/2002 - "The lower axon terminal level of GABA in younger rats may help to explain the age-dependency of pain development in animal models of nerve injury." 11/19/2008 - "The results of the present study showed that locally released GABA in the CeA is involved in pain modulation and suggests the existence of a GABA(A) mediated inhibitory system in the CeA on pain control." Order ALL the reference details at left...
4.	Ischemia 08/01/1994 - "The enhanced GABA release may be one of the possible mechanisms of neuronal protection against ischemia in adrenelectomized gerbils." 01/01/2009 - "The localization of mGlu1 receptors in GABA-containing interneurons rather than in hippocampal CA1 pyramidal cells that are vulnerable to ischemia has prompted experimental studies that have demonstrated mGlu1 receptor antagonist agents attenuate postischemic injury by enhancing GABA-mediated neurotransmission, thus providing a new viewpoint on the neuroprotective mechanism of these pharmacological agents. " 09/01/2003 - "The localization of mGlu(1) receptors in GABA-containing interneurons rather than in hippocampal CA1 pyramidal cells that are vulnerable to ischemia has prompted studies that have provided a new viewpoint on the neuroprotective mechanism of mGlu(1) receptor antagonists. " 11/10/2000 - "The present study was undertaken to determine the alteration of GABA-T expression in the gerbil hippocampus after ischemia-reperfusion. " 01/01/1993 - "The object is to verify if the interneurons die or survive after an ischemic insult, and study if ischemia changes GABA inhibition in the period preceding delayed CA1 pyramidal cell death. " Order ALL the reference details at left...
5.	Mood Disorders (Mood Disorder) 03/15/2007 - "The aim of this study was to use MRS to determine whether changes in GABA and Glu levels were present in patients with mood disorders who had recovered and were no longer taking medication. " 05/23/2006 - "Also, clinical studies have reported low level in mood disorder patients for both plasma and cerebrospinal fluid (CSF) GABA. " 08/01/2003 - "Preclinical studies have suggested that GABA levels may be decreased in animal models of depression, and clinical studies reported low plasma and CSF GABA levels in mood disorder patients. " 01/01/1998 - "In this study, we investigated the possibility that the gene for the gamma-aminobutyric acid type A (GABAA) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. " 01/01/1998 - "Over the past twenty years, several lines of evidence from preclinical and clinical studies has accumulated suggesting that a GABA deficit may be involved in mood disorders, particularly in depression, and that increasing GABAergic neurotransmission may exert an antidepressant effect and perhaps a mood stabilizing effect. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Anticonvulsants (Antiepileptic Drugs)
3.	gabapentin (Neurontin)
4.	Vigabatrin
5.	Glutamic Acid (Glutamate)
6.	Neurotransmitter Agents (Neurotransmitter)
7.	Baclofen
8.	Valproic Acid (Valproate, Semisodium)
9.	GABA-A Receptors (GABA(A) Receptor)
10.	Diazepam (Valium)

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Intravenous Injections
4.	Ketogenic Diet
5.	Caloric Restriction

blog comments powered by Disqus

TREATMENT OPTIONS
for Seizures,
Ranking and Evidence

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. Analytic charts allow you and your physicians to see at a glance the treatment options—including new, promising, off-label and experimental.

Free Updates for 1 Year
All 2217 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Evidence References
Sample PDF Report on Psoriasis >>

Price:

$8.50 USD & Delivery via PDF download
updates for 1 year

Research Interface PRO

Rapidly retrieve clinical outcome summaries for all evidence of drug efficacy against any disease in seconds. Click "Charts" to view graphs of relative efficacy of all drugs against any known disease. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time. Save hours of search and analysis time:

Two-clicks from Disease to Drug to Evidence: Drill down to full abstract
Enable Experts: Quickly identify key researchers and their publications
Enable FDA Link Generic: Two-clicks to FDA Products/Patents/Generics
Enable Export: All outcome statements and scores exportable to Excel/TSV for automated meta-analysis
Research Network: Explore drug and disease relationships visually
Enable Mobile Interface: Access from your cellphone, iPhone or PDA

Price:

$45.00 USD access via web interface
1 year subscription

Request Bulk Institution License Details >>