Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma.

Abstract

Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC.

• Authors: Sha-Sha Wang, Xiao Cen, Xin-Hua Liang, Ya-Ling Tang
• Journal: Oncotarget (Oncotarget) Vol. 8 Issue 6 Pg. 10650-10661 (Feb 07 2017) ISSN: 1949-2553 [Electronic] United States
• PMID: 27788497 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers, Tumor
• Inflammation Mediators
• Macrophage Migration-Inhibitory Factors
• Intramolecular Oxidoreductases
• MIF protein, human

Topics

• Animals
• Apoptosis
• Autophagy
• Biomarkers, Tumor (genetics, metabolism)
• Carcinoma, Squamous Cell (genetics, immunology, metabolism, pathology)
• Cell Proliferation
• Epithelial-Mesenchymal Transition
• Head and Neck Neoplasms (genetics, immunology, metabolism, pathology)
• Humans
• Inflammation Mediators (metabolism)
• Intramolecular Oxidoreductases (genetics, metabolism)
• Macrophage Migration-Inhibitory Factors (genetics, metabolism)
• Neovascularization, Pathologic
• Signal Transduction
• Squamous Cell Carcinoma of Head and Neck
• Tumor Hypoxia
• Tumor Microenvironment