Allergic airway disease caused by methyl tetrahydrophthalic anhydride in epoxy resin.

Abstract	Work-associated rhinitis and asthma occurred in a subject exposed to methyl tetrahydrophthalic anhydride (MTHPA) used as a curing agent in an epoxy resin system. He displayed bronchial hyperreactivity in provocation with methacholine, as well as skin prick test positivity and specific immunoglobulin E (IgE) serum antibodies, against a conjugate of MTHPA and human serum albumin. Thus, it seems likely that the disease was caused by an IgE-mediated allergy.
Authors	J Nielsen, H Welinder, S Skerfving
Journal	Scandinavian journal of work, environment & health (Scand J Work Environ Health) Vol. 15 Issue 2 Pg. 154-5 (Apr 1989) ISSN: 0355-3140 [Print] Finland
PMID	2772578 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Phthalic Acids Phthalic Anhydrides Immunoglobulin E
Topics	Adult Asthma (chemically induced, immunology) Humans Immunoglobulin E (analysis) Male Occupational Diseases (chemically induced, immunology) Phthalic Acids (adverse effects) Phthalic Anhydrides (adverse effects) Respiratory Hypersensitivity (chemically induced, immunology) Rhinitis (chemically induced, immunology)

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