Abstract | PURPOSE: METHODS: RESULTS: The casitas B lineage lymphoma-b (Cbl-b), a kind of E3 ubiquitin ligase, was involved in this process. Specific silenced Cbl-b expression increased the expression of EGFR. CONCLUSIONS: Our findings lead to a better understanding of the mechanism of cetuximab action, and suggests that Cbl-b increases the sensitivity of cetuximab in gastric cancer cells.
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Authors | Ping Yu, Yibo Fan, Xiujuan Qu, Jingdong Zhang, Na Song, Jing Liu, Yunpeng Liu |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2016 Jul-Aug
Vol. 21
Issue 4
Pg. 867-873
ISSN: 1107-0625 [Print] Cyprus |
PMID | 27685907
(Publication Type: Journal Article)
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Chemical References |
- Adaptor Proteins, Signal Transducing
- Antibodies, Monoclonal
- Antineoplastic Agents
- Ubiquitin
- CBLB protein, human
- Proto-Oncogene Proteins c-cbl
- EGFR protein, human
- ErbB Receptors
- Proteasome Endopeptidase Complex
- Cetuximab
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Topics |
- Adaptor Proteins, Signal Transducing
(metabolism)
- Antibodies, Monoclonal
(pharmacology)
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Cell Line, Tumor
- Cetuximab
(pharmacology)
- Drug Resistance, Neoplasm
(physiology)
- ErbB Receptors
(metabolism)
- Humans
- Proteasome Endopeptidase Complex
(metabolism)
- Proto-Oncogene Proteins c-cbl
(metabolism)
- Stomach Neoplasms
(drug therapy, metabolism)
- Ubiquitin
(metabolism)
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