Is there a role of Tau in Huntington's disease?

Abstract

Alterations of the cerebrospinal fluid (CSF) composition are useful clinical diagnostic tools as well as a source of candidates for new biomarkers of neurodegenerative disorders. This Editorial highlights a study by Rodrigues and colleagues in which the authors try to establish Tau as a new biomarker for Huntington´s disease (HD). The study confirmed in two independent, age-controlled patient populations at various disease stages, asymptomatic mutation carriers and healthy controls, that CSF total Tau concentrations in HD gene mutation carriers are increased compared with healthy controls. This is a strong evidence that CSF total Tau concentration is associated with phenotypic variability in HD. Read the highlighted article 'Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease' on page 22.

• Authors: Inga Zerr, Mathias Bähr
• Journal: Journal of neurochemistry (J Neurochem) Vol. 139 Issue 1 Pg. 9-10 (10 2016) ISSN: 1471-4159 [Electronic] England
• PMID: 27651306 (Publication Type: Editorial)
• Copyright: © 2016 International Society for Neurochemistry.

Chemical References

• Biomarkers
• tau Proteins

Topics

• Biomarkers (cerebrospinal fluid)
• Humans
• Huntington Disease (cerebrospinal fluid)
• Predictive Value of Tests
• tau Proteins (cerebrospinal fluid)