Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

Abstract

A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.

• Authors: Charlotte Welinder, Karin Jirström, Sophie Lehn, Björn Nodin, György Marko-Varga, Ola Blixt, Lena Danielsson, Bo Jansson
• Journal: Heliyon (Heliyon) Vol. 2 Issue 8 Pg. e00143 (Aug 2016) ISSN: 2405-8440 [Print] England
• PMID: 27579449 (Publication Type: Journal Article)