Steroid receptor RNA activator: Biologic function and role in disease.

Abstract

Steroid receptor RNA activator (SRA) is a type of long noncoding RNA (lncRNA) which coordinates the functions of various transcription factors, enhances steroid receptor-dependent gene expression, and also serves as a distinct scaffold. The novel, profound and expanded roles of SRA are emerging in critical aspects of coactivation of nuclear receptors (NRs). As a nuclear receptor coactivator, SRA can coactivate androgen receptor (AR), estrogen receptor α (ERα), ERβ, progesterone receptor (PR), glucocorticoid receptor (GR), thyroid hormone receptor and retinoic acid receptor (RAR). Although SRA is one of the least well-understood molecules, increasing studies have revealed that SRA plays a key role in both biological processes, such as myogenesis and steroidogenesis, and pathological changes, including obesity, cardiomyopathy, and tumorigenesis. Furthermore, the SRA-related signaling pathways, such as the mitogen-activated protein kinase (p38 MAPK), Notch and tumor necrosis factor α (TNFα) pathways, play critical roles in the pathogenesis of estrogen-dependent breast cancers. In addition, the most recent data demonstrates that SRA expression may serve as a new prognostic marker in patients with ER-positive breast cancer. Thus, elucidating the molecular mechanisms underlying SRA-mediated functions is important to develop proper novel strategies to target SRA in the diagnosis and treatment of human diseases.

• Authors: Chan Liu, Hong-Tao Wu, Neng Zhu, Ya-Ning Shi, Zheng Liu, Bao-Xue Ao, Duan-Fang Liao, Xi-Long Zheng, Li Qin
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 459 Pg. 137-146 (Aug 01 2016) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 27282881 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• RNA, Long Noncoding
• steroid receptor RNA activator

Topics

• Cardiovascular Diseases (metabolism)
• Female
• Humans
• Neoplasms (metabolism)
• Obesity (metabolism)
• Polycystic Ovary Syndrome (metabolism)
• RNA, Long Noncoding (chemistry, genetics, metabolism)