Dietary supplementation with Lactobacillus plantarum dy-1 fermented barley suppresses body weight gain in high-fat diet-induced obese rats.

Abstract

BACKGROUND:

Cereal fermentations have shown significant potential in improvement and design of the nutritional quality and health effects of foods and ingredients. In the present study, the effect of supplementary Lactobacillus plantarum dy-1 fermented barley (LFB) on obesity in high-fat diet (HFD)-induced obese rats was investigated.

RESULTS:

LFB treatment showed a lower rate of increase in body weight and percentage of body fat and a reversal of HFD-induced glucose intolerance, with ameliorated hyperinsulinemia, decreased levels of triglycerides and total cholesterol, and inhibited concentration of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α. Moreover, LFB treatment also showed the strongest inhibition of nuclear factor (NF)-kB activation and exhibited the greatest effects in blocking the degradation of the inhibitor of NF-kB and inhibiting p38 and JNK1 phosphorylation compared with HFD and raw barley treatment.

CONCLUSIONS:

It was clear that Lactobacillus plantarum dy-1 fermentation significantly improves the anti-obesity properties of barley. The results establish the foundation for ameliorating diet-induced obesity of product with LFB as nutritional supplements. © 2016 Society of Chemical Industry.

• Authors: Jiayan Zhang, Xiang Xiao, Ying Dong, Tian Xu, Fei Wu
• Journal: Journal of the science of food and agriculture (J Sci Food Agric) Vol. 96 Issue 15 Pg. 4907-4917 (Dec 2016) ISSN: 1097-0010 [Electronic] England
• PMID: 27145037 (Publication Type: Journal Article)
• Copyright: © 2016 Society of Chemical Industry.

Chemical References

• Anti-Obesity Agents
• Insulin
• Interleukin-1beta
• Interleukin-6
• NF-kappa B
• Triglycerides
• Tumor Necrosis Factor-alpha
• Cholesterol

Topics

• Animals
• Anti-Obesity Agents
• Cholesterol (blood)
• Diet, High-Fat
• Dietary Supplements
• Fermentation
• Glucose Intolerance (diet therapy)
• Hordeum (metabolism)
• Insulin (blood)
• Interleukin-1beta (blood)
• Interleukin-6 (blood)
• Lactobacillus plantarum (metabolism)
• Male
• NF-kappa B (antagonists & inhibitors)
• Obesity (diet therapy, etiology, physiopathology)
• Rats
• Rats, Sprague-Dawley
• Triglycerides (blood)
• Tumor Necrosis Factor-alpha (blood)
• Weight Gain