Abstract |
Auto- antibodies against aminoacyl- tRNA- synthetases (anti-ARS Abs) represent the hallmark of the anti- synthetase syndrome that is defined as the clinical association of fever, Raynaud's phenomenon, myositis, interstitial lung disease (ILD), arthritis and mechanic's hands. Recently, differences in clinical features depending on specific anti-ARS Abs have been reported. We describe three cases of anti-EJ (anti-glycyl) antibody-positive patients presenting with ILD as a common feature, but with heterogeneous histopathological and radiographic patterns and with different responses to treatment. Relapsing- remittent fever, refractory muscle involvement and seronegative arthritis were also striking clinical manifestations.
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Authors | Margherita Giannini, Antonella Notarnicola, Maryam Dastmalchi, Ingrid E Lundberg, Giuseppe Lopalco, Florenzo Iannone |
Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 35
Issue 9
Pg. 2363-7
(Sep 2016)
ISSN: 1434-9949 [Electronic] Germany |
PMID | 27068736
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Autoantibodies
- Amino Acyl-tRNA Synthetases
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Topics |
- Adult
- Amino Acyl-tRNA Synthetases
(immunology)
- Autoantibodies
(immunology)
- Female
- Humans
- Lung Diseases, Interstitial
(complications, immunology)
- Middle Aged
- Myositis
(complications, immunology)
- Young Adult
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