Abstract | OBJECTIVE: METHODS: RESULTS: An indication for an insulin dose adjustment was identified in 32 and 42% of patients on day -2 and day -1, respectively, before the index hypoglycemic event, of which 35 and 55%, respectively, had an insulin dose reduction ≥10%. Following the hypoglycemic event, 44% of patients had an insulin dose reduction of ≥20%. Therapeutic reduction of the total daily insulin dose by ≥20% was associated with increased odds of normoglycemia and lower odds of hyperglycemia but was not associated with lower odds of recurrent hypoglycemia on the day following the index hypoglycemic event. There was a high prevalence of hypoglycemic risk factors in this population, with kidney disease and nil per os status being the most prevalent contributing factors. CONCLUSION: Adherence to the current practice recommendation to reduce insulin doses in patients with borderline hypoglycemia and following overt hypoglycemia was modest. Further studies are needed to understand the associated risks and to define appropriate therapeutic changes for insulin treated patients with borderline and overt hypoglycemia. ABBREVIATIONS:
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Authors | Nestoras Mathioudakis, Estelle Everett, Sherita Hill Golden |
Journal | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
(Endocr Pract)
Vol. 22
Issue 8
Pg. 959-69
(Aug 2016)
ISSN: 1530-891X [Print] United States |
PMID | 27042740
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Blood Glucose
(analysis)
- Diabetes Complications
(drug therapy, epidemiology)
- Dose-Response Relationship, Drug
- Female
- Hospitalization
(statistics & numerical data)
- Humans
- Hyperglycemia
(complications, drug therapy, epidemiology)
- Hypoglycemia
(chemically induced, epidemiology, prevention & control, therapy)
- Insulin
(administration & dosage, adverse effects)
- Kidney Failure, Chronic
(complications, drug therapy, epidemiology)
- Male
- Middle Aged
- Prevalence
- Retrospective Studies
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