Elevated serum levels of MMP-11 correlate with poor prognosis in colon cancer patients.

Abstract

BACKGROUND:

Matrix metalloproteinase 11 (MMP11) has been shown to play a key role in human tumor progression and indicates poor clinical outcome in cancer patients.

OBJECTIVE:

The current study aimed to evaluate the relationship between serum levels of MMP-11 and prognosis in colon cancer patients.

METHODS:

Serum levels of MMP-11 were determined in 92 colon cancer patients and 92 healthy individuals using an enzyme-linked immunosorbent assay (ELISA). Associations between serum MMP-11 levels and clinicopathological characteristics of the patients and their outcomes were investigated. Survival analyses were performed to measure the 5-year overall survival (OS) and disease-free survival (DFS).

RESULTS:

Serum MMP-11 levels were substantially higher in colon cancer patients than in healthy controls. Moreover, serum MMP-11 levels were significantly higher in patients with advanced T status, lymph node metastasis, distant metastasis, and a higher TNM stage. Elevated serum levels of MMP-11 were identified as an independent prognostic factor for 5-year mortality and adverse events associated with colon cancer. Multivariate Cox regression analysis identified the serum MMP-11 level as an independent predictor of OS and DFS.

CONCLUSION:

Our study established that high serum levels of MMP-11 are associated with poor clinical outcome and may serve as a prognostic biomarker in colon cancer patients.

• Authors: Li Pang, Da-Wei Wang, Nan Zhang, Da-Hai Xu, Xiang-Wei Meng
• Journal: Cancer biomarkers : section A of Disease markers (Cancer Biomark) Vol. 16 Issue 4 Pg. 599-607 (Mar 11 2016) ISSN: 1875-8592 [Electronic] Netherlands
• PMID: 27002762 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• MMP11 protein, human
• Matrix Metalloproteinase 11

Topics

• Adult
• Aged
• Biomarkers, Tumor
• Case-Control Studies
• Colonic Neoplasms (blood, diagnosis, drug therapy, mortality)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Matrix Metalloproteinase 11 (blood)
• Middle Aged
• Neoplasm Grading
• Neoplasm Metastasis
• Neoplasm Staging
• Prognosis
• ROC Curve