The C-reactive Protein to Albumin Ratio Predicts Long-Term Outcomes in Patients with Pancreatic Cancer After Pancreatic Resection.

Abstract

BACKGROUND:

The C-reactive protein to albumin (CRP/Alb) ratio, a novel inflammation-based prognostic score, is associated with outcomes in septic patients. The prognostic value of CRP/Alb ratio has not been established in cancer patients. The aim of this study is to evaluate the significance of CRP/Alb ratio in therapeutic outcome after pancreatic resection for pancreatic cancer.

METHODS:

The study comprised 113 patients who had undergone pancreatic resection for pancreatic cancer between April 2001 and December 2011. We retrospectively investigated the relation between CRP/Alb ratio and disease-free as well as overall survival.

RESULTS:

The optimal cut-off level of the CRP/Alb ratio was 0.03. For disease-free survival, preoperative biliary drainage (p = 0.011), advanced tumor-node-metastasis (TNM) classification (p = 0.002), and higher CRP/Alb ratio (p = 0.049) by univariate analysis, and advanced TNM classification (p = 0.003) by multivariate analysis, were independent and significant predictors of cancer recurrence. For overall survival, preoperative biliary drainage (p = 0.012), advanced TNM classification (p = 0.001), and higher CRP/Alb ratio (p = 0.023) by univariate analysis, and advanced TNM classification (p = 0.003) and higher CRP/Alb ratio (p = 0.035) by multivariate analysis, were independent and significant predictors of poor patient outcome.

CONCLUSIONS:

The CRP/Alb ratio may be an independent and significant indicator of poor long-term outcomes in patients with pancreatic cancer after pancreatic resection.

• Authors: Koichiro Haruki, Hiroaki Shiba, Yoshihiro Shirai, Takashi Horiuchi, Ryota Iwase, Yuki Fujiwara, Kenei Furukawa, Takeyuki Misawa, Katsuhiko Yanaga
• Journal: World journal of surgery (World J Surg) Vol. 40 Issue 9 Pg. 2254-60 (Sep 2016) ISSN: 1432-2323 [Electronic] United States
• PMID: 26956901 (Publication Type: Journal Article)

Chemical References

• Serum Albumin
• C-Reactive Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• C-Reactive Protein (analysis)
• Female
• Humans
• Japan (epidemiology)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (blood)
• Pancreatectomy
• Pancreatic Neoplasms (mortality, surgery)
• Prognosis
• Retrospective Studies
• Serum Albumin