Abstract | OBJECTIVES: To assess the effects of urinary diversion on renal function, we retrospectively investigated renal function over 5 years after urinary diversion using a propensity score matching strategy. METHODS: Between May 1996 and November 2013, 345 consecutive adult patients underwent radical cystectomy and urinary diversion in our hospital; one hundred and fifteen patients with more than a 5-year follow-up were enrolled. Propensity scores were calculated using logistic analysis, and the data used in the analyses included age, gender, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), clinical tumor stage, presence of cardiovascular disease; hypertension; and type 2 diabetes and preoperative eGFR at the initial visit. Multivariate logistic regression analysis was used to assess the risk factors for stage 3B chronic kidney disease (CKD) after the different types of urinary diversion. RESULTS: Continent and incontinent diversion were performed in 68 and 47 patients, respectively. The mean preoperative eGFR was significantly lower in the incontinent than in the continent group (P < 0.001). In propensity score-matched patients (n = 34 each), no significant differences were observed in pre- and postoperative eGFR and 5-year eGFR decrease rates between the groups. In the incontinent group, the number of postoperative stage 3B CKD patients was significantly increased than the continent group. Using multivariate analysis, independent risk factors significantly associated with stage 3B CKD at 5 years after surgery were older age, eGFR before surgery, incontinent diversion (cutaneous ureterostomy), and postoperative hydronephrosis. CONCLUSIONS:
|
Authors | Shingo Hatakeyama, Takuya Koie, Takuma Narita, Shogo Hosogoe, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama |
Journal | PloS one
(PLoS One)
Vol. 11
Issue 2
Pg. e0149544
( 2016)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26901860
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Aged
- Female
- Humans
- Male
- Middle Aged
- Postoperative Period
- Renal Insufficiency, Chronic
(physiopathology, surgery)
- Retrospective Studies
- Risk Factors
- Urinary Bladder
- Urinary Bladder Neoplasms
(surgery)
- Urinary Diversion
|