Abstract | OBJECTIVE: MATERIALS/METHODS: Ambulatory function of 180 symptomatic men and women with PAD was assessed during a graded maximal treadmill test, 6-minute walk test, and 4-meter walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells, and on circulating inflammatory and vascular biomarkers. RESULTS: Men and women with diabetes had greater prevalence (p = 0.007 and p = 0.015, respectively) of coronary artery disease (CAD) than patients without diabetes. To assure that this difference did not influence planned comparisons, the data set was stratified on CAD. Diabetic men with CAD had a lower peak walking time (PWT) during the treadmill test and a slower 4-meter gait speed compared to non-diabetic men with CAD (p < 0.05). Diabetic women with CAD had a lower PWT compared to their non-diabetic counterparts (p < 0.01). Additionally, diabetic men with CAD had higher pigment epithelium-derived factor (p < 0.05) than their non-diabetic counterparts, and diabetic women with CAD had higher leptin (p < 0.01) and interleukin-8 levels (p < 0.05). CONCLUSIONS: In patients with PAD, diabetic men and women with CAD had more severe claudication than their non-diabetic counterparts, as measured by shorter PWT, and the men had further ambulatory impairment manifested by slower 4-meter gait speed. Furthermore, the diabetic patients with CAD had elevations in interleukin-8, leptin, and PEDF.
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Authors | Andrew W Gardner, Donald E Parker, Polly S Montgomery, Danuta Sosnowska, Ana I Casanegra, Zoltan Ungvari, Anna Csiszar, Sarah X Zhang, Josh J Wang, William E Sonntag |
Journal | Journal of clinical & translational endocrinology
(J Clin Transl Endocrinol)
Vol. 2
Issue 4
Pg. 137-143
(Dec 01 2015)
ISSN: 2214-6237 [Print] Netherlands |
PMID | 26835254
(Publication Type: Journal Article)
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