Abstract | OBJECTIVE: DESIGN, SETTING, AND PARTICIPANT: This was a prospective observational study of 253 consecutive patients with DTC who underwent rhTSH-aided RAI ablation after total thyroidectomy and prophylactic CND. Patients with evidence of initial distant metastasis or positive Tg antibodies were excluded. MAJOR OUTCOME MEASURE: We compared rhTSH-stimulated Tg level at RAI ablation according to the disease status at 1 year and evaluated optimal cut-off value of rhTSH-stimulated Tg. Binary logistic regression analysis was performed to investigate the independent predictive factors for disease status 1 year after ablation. RESULTS: Among study participants, 228 (90·1%) were considered disease free at 1 year after remnant ablation. Patients with persistent or recurrent disease were more likely to be aged ≥45 years, and to have N1b stage, TNM stage III or IV, and higher rhTSH-stimulated Tg level at RAI ablation. The optimal cut-off of rhTSH-stimulated Tg for predicting persistent or recurrent disease was 1·79 ng/ml, with a negative predictive value of 99·5%. A serum rhTSH-stimulated Tg level ≥1·79 at the time of ablation was independently associated with persistent or recurrent disease 1 year later. N1b stage tended to be associated with persistent or recurrent disease. CONCLUSION: A low stimulated serum Tg level at rhTSH-aided RAI ablation may be a favourable prognostic marker in the setting of prophylactic CND.
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Authors | Jae Hoon Moon, June Young Choi, Woo-Jin Jeong, Soon-Hyun Ahn, Won Woo Lee, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Ka Hee Yi, Do Joon Park, Hak Chul Jang |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 85
Issue 3
Pg. 459-65
(09 2016)
ISSN: 1365-2265 [Electronic] England |
PMID | 26833982
(Publication Type: Journal Article)
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Copyright | © 2016 John Wiley & Sons Ltd. |
Chemical References |
- Iodine Radioisotopes
- Recombinant Proteins
- Thyrotropin
- Thyroglobulin
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Topics |
- Ablation Techniques
(methods)
- Adult
- Aged
- Female
- Humans
- Iodine Radioisotopes
(therapeutic use)
- Male
- Middle Aged
- Neck Dissection
(methods)
- Prognosis
- Recombinant Proteins
(pharmacology)
- Thyroglobulin
(blood)
- Thyroid Neoplasms
(pathology, surgery)
- Thyrotropin
(pharmacology)
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