Abstract | BACKGROUND: METHODS: Forty-three participants were investigated at admission for an acute exacerbation of COPD, and reassessed when stable. Forty-three controls were matched for age, gender, body mass index, smoking index, comorbidities and medication use. Participants underwent pulmonary function and laboratory testing, including the measurements of D-dimer and high-sensitivity C-reactive protein ( hsCRP). RESULTS: The median of D-dimer was 2839 μg/l (IQR: 2078-4389 μg/l) and 1799 μg/l (IQR: 1205-2196 μg/l) in exacerbated and stable COPD patients respectively. The median of D-dimer in the control subjects was 433 μg/l (IQR: 369-456 μg/l). D-dimer level was significantly increased in stable COPD patients compared with healthy controls, and further increased in those patients with an acute exacerbation (both P<0.001). D-dimer was positively correlated with the well-known inflammatory marker hsCRP both in the exacerbated and stable phases of COPD (r=0.392 P=0.009 and r=0.411 P=0.006, respectively), and negatively correlated with FEV1% predicted and FEV1/FVC in stable COPD (r=-0.409 P=0.006 and r=-0.343 P=0.024, respectively). CONCLUSIONS:
D-dimer is increased in COPD patients, and could be considered as an inflammatory marker for the assessment of inflammation in the progression of COPD.
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Authors | Ming Zhang, Jie Zhang, Qiuhong Zhang, Xia Yang, Hu Shan, Zongjuan Ming, Haijuan Chen, Yanqin Liu, Jiafeng Yin, Yali Li |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 455
Pg. 55-9
(Apr 01 2016)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 26826394
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Fibrin Fibrinogen Degradation Products
- fibrin fragment D
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Topics |
- Aged
- Biomarkers
(blood)
- Case-Control Studies
- Disease Progression
- Female
- Fibrin Fibrinogen Degradation Products
(metabolism)
- Humans
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
(blood, physiopathology)
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