Abstract |
The translocator protein, a microglial-expressed marker of neuroinflammation, has been implicated in Alzheimer's disease, which is characterized by alterations in vascular and inflammatory states. ATSPOvariant, rs6971, determines binding affinity of exogenous radioligandsin vivo; however, the effect of these altered binding characteristics on inflammatory and cerebrovascular biomarkers has not been assessed. In 2345 living subjects ( Alzheimer's Disease Neuroimaging Initiative, n = 1330) and postmortem brain samples (Religious Orders Study and Memory and Aging Project, n = 1015), we analyzed effects of rs6971 on white matter hyperintensisites, cerebral infarcts, circulating inflammatory biomarkers, amyloid angiopathy, and microglial activation. We found that rs6971 does not alter translocator protein in a way that impacts cerebrovascular and inflammatory states known to be affected in dementia.
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Authors | Daniel Felsky, Philip L De Jager, Julie A Schneider, Konstantinos Arfanakis, Debra A Fleischman, Zoe Arvanitakis, William G Honer, Jennie G Pouget, Romina Mizrahi, Bruce G Pollock, James L Kennedy, David A Bennett, Aristotle N Voineskos, authors of the Alzheimer’s Disease Neuroimaging Initiative |
Journal | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
(J Cereb Blood Flow Metab)
Vol. 36
Issue 4
Pg. 819-30
(Apr 2016)
ISSN: 1559-7016 [Electronic] United States |
PMID | 26762507
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2016. |
Chemical References |
- Biomarkers
- Reactive Oxygen Species
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Topics |
- Aged
- Aging
(pathology)
- Alzheimer Disease
(pathology)
- Arterial Pressure
- Biomarkers
(analysis)
- Brain
(pathology)
- Cerebral Amyloid Angiopathy
(genetics, pathology)
- Cerebral Infarction
(pathology)
- Cerebrovascular Circulation
(genetics)
- Female
- Genetic Variation
- Humans
- Inflammation
(genetics)
- Male
- Microglia
- Reactive Oxygen Species
(metabolism)
- White Matter
(pathology)
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