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Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant.

Abstract
The translocator protein, a microglial-expressed marker of neuroinflammation, has been implicated in Alzheimer's disease, which is characterized by alterations in vascular and inflammatory states. ATSPOvariant, rs6971, determines binding affinity of exogenous radioligandsin vivo; however, the effect of these altered binding characteristics on inflammatory and cerebrovascular biomarkers has not been assessed. In 2345 living subjects (Alzheimer's Disease Neuroimaging Initiative, n = 1330) and postmortem brain samples (Religious Orders Study and Memory and Aging Project, n = 1015), we analyzed effects of rs6971 on white matter hyperintensisites, cerebral infarcts, circulating inflammatory biomarkers, amyloid angiopathy, and microglial activation. We found that rs6971 does not alter translocator protein in a way that impacts cerebrovascular and inflammatory states known to be affected in dementia.
AuthorsDaniel Felsky, Philip L De Jager, Julie A Schneider, Konstantinos Arfanakis, Debra A Fleischman, Zoe Arvanitakis, William G Honer, Jennie G Pouget, Romina Mizrahi, Bruce G Pollock, James L Kennedy, David A Bennett, Aristotle N Voineskos, authors of the Alzheimer’s Disease Neuroimaging Initiative
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 36 Issue 4 Pg. 819-30 (Apr 2016) ISSN: 1559-7016 [Electronic] United States
PMID26762507 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Copyright© The Author(s) 2016.
Chemical References
  • Biomarkers
  • Reactive Oxygen Species
Topics
  • Aged
  • Aging (pathology)
  • Alzheimer Disease (pathology)
  • Arterial Pressure
  • Biomarkers (analysis)
  • Brain (pathology)
  • Cerebral Amyloid Angiopathy (genetics, pathology)
  • Cerebral Infarction (pathology)
  • Cerebrovascular Circulation (genetics)
  • Female
  • Genetic Variation
  • Humans
  • Inflammation (genetics)
  • Male
  • Microglia
  • Reactive Oxygen Species (metabolism)
  • White Matter (pathology)

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