Glycomacropeptide administration attenuates airway inflammation and remodeling associated to allergic asthma in rat.

Abstract

OBJECTIVE:

Glycomacropeptide (GMP) is a bioactive peptide derived from milk that has been reported to exhibit a range of anti-inflammatory and immunomodulatory properties. The aim of this study was to analyze the prophylactic effect of GMP administration on airway inflammation and remodeling in an experimental model of asthmatic rat.

METHODS:

Animals treated orally with or without GMP (500 mg/kg/day) were ovalbumin-sensitized and -nebulized and several indicators of Th2 response, airway structural changes and inflammatory cells recruitment were evaluated.

RESULTS:

Treatment with GMP prior and during asthma development resulted in reduction of allergen-specific IgE titers in serum and blood eosinophilia. Also, GMP substantially suppressed the recruitment of inflammatory cells to bronchoalveolar compartment. Histological studies demonstrated that GMP markedly inhibits eosinophils infiltration, goblet cells hyperplasia and collagen deposit in lung tissue. The latter effect was related with an inhibition in transforming growth factor-β expression. In addition, expression of interleukin-5 and -13 were substantially inhibited in lung while that of interleukin-10 was increased.

CONCLUSION:

Our results suggest that administration of GMP may prevent the development of an excessive Th2 response in asthma and effectively ameliorates the progression of the disease.

• Authors: Nuria Renata Roldán, Mariela Jiménez, Daniel Cervantes-García, Estefanía Marín, Eva Salinas
• Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (Inflamm Res) Vol. 65 Issue 4 Pg. 273-83 (Apr 2016) ISSN: 1420-908X [Electronic] Switzerland
• PMID: 26755379 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Allergens
• Anti-Asthmatic Agents
• Anti-Inflammatory Agents
• Bacterial Vaccines
• Caseins
• Cytokines
• Peptide Fragments
• caseinomacropeptide
• Immunoglobulin E
• Ovalbumin

Topics

• Administration, Oral
• Airway Remodeling (drug effects)
• Allergens (immunology)
• Animals
• Anti-Asthmatic Agents (pharmacology, therapeutic use)
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Asthma (drug therapy, immunology, pathology)
• Bacterial Vaccines (immunology)
• Bordetella (immunology)
• Bronchoalveolar Lavage Fluid
• Caseins (pharmacology, therapeutic use)
• Cell Count
• Cytokines (genetics)
• Disease Models, Animal
• Immunoglobulin E (blood)
• Lung (drug effects, metabolism, pathology)
• Male
• Ovalbumin (immunology)
• Peptide Fragments (pharmacology, therapeutic use)
• Rats, Wistar
• Th2 Cells (drug effects, immunology)