Abstract | BACKGROUND: The characterization of the first episode of psychosis and how it should be treated are principal issues in actual research. Realistic, naturalistic studies are necessary to represent the entire population of first episode of psychosis attended in daily practice. METHODS: Sixteen participating centers from the PEPs project recruited 335 first episode of psychosis patients, aged 7 to 35 years. This article describes and discusses the psychopharmacological interventions and safety profiles at baseline and during a 60-day pharmacovigilance period. RESULTS: CONCLUSIONS: These data indicate that the overall pharmacologic prescription for treating a first episode of psychosis in Spain follows the clinical practice guideline recommendations, and, together with security issues, support future research of determinate pharmacological strategies for the treatment of early phases of psychosis, such as the role of clozapine, long-acting injectable antipsychotics, antipsychotic combination, and the use of benzodiazepines.
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Authors | Miquel Bioque, Adrián Llerena, Bibiana Cabrera, Gisela Mezquida, Antonio Lobo, Ana González-Pinto, Covadonga M Díaz-Caneja, Iluminada Corripio, Eduardo J Aguilar, Antoni Bulbena, Josefina Castro-Fornieles, Eduard Vieta, Amàlia Lafuente, Sergi Mas, Mara Parellada, Jerónimo Saiz-Ruiz, Manuel J Cuesta, Miguel Bernardo, PEPs GROUP |
Journal | The international journal of neuropsychopharmacology
(Int J Neuropsychopharmacol)
Vol. 19
Issue 4
(Apr 2016)
ISSN: 1469-5111 [Electronic] England |
PMID | 26506856
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2015. Published by Oxford University Press on behalf of CINP. |
Chemical References |
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Topics |
- Acute Disease
- Adolescent
- Adult
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Child
- Female
- Humans
- Logistic Models
- Male
- Pharmacovigilance
- Polypharmacy
- Psychiatric Status Rating Scales
- Psychotic Disorders
(drug therapy, epidemiology)
- Sex Factors
- Spain
(epidemiology)
- Treatment Outcome
- Young Adult
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