Abstract | INTRODUCTION: MATERIAL AND METHODS: In a prospective study, vaginally obtained amniotic fluid samples were collected from 53 women with preterm prelabor rupture of membranes at 23(+4) to 34(+5) weeks of gestation at University Hospital, Helsinki, Finland. Amniotic fluid lactate dehydrogenase and amniotic fluid glucose were measured by immunochemiluminometric assays. Histopathologic examination of placenta was performed. The main outcome measure was histologic chorioamnionitis. RESULTS: Median concentration of vaginally obtained amniotic fluid lactate dehydrogenase was higher in women with histologic chorioamnionitis than in women without (1400 IU/L vs. 784.5 IU/L, p = 0.005). By receiver operating characteristics curve the optimal cut-off for amniotic fluid lactate dehydrogenase in relation to histologic chorioamnionitis was 1029 IU/L (sensitivity 65%, specificity 69%, positive predictive value 83% and negative predictive value 46%). Amniotic fluid lactate dehydrogenase concentrations showed striking fluctuation in repeat samples. Amniotic fluid glucose concentrations did not differ among women with or without histologic chorioamnionitis (0 mmol/L vs. 0.65 mmol/L, p = 0.20). CONCLUSION:
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Authors | Tarja Myntti, Leena Rahkonen, Minna Tikkanen, Jorma Paavonen, Vedran Stefanovic |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 95
Issue 2
Pg. 233-7
(Feb 2016)
ISSN: 1600-0412 [Electronic] United States |
PMID | 26471933
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Nordic Federation of Societies of Obstetrics and Gynecology. |
Chemical References |
- L-Lactate Dehydrogenase
- Glucose
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Topics |
- Adult
- Amniotic Fluid
(chemistry)
- Chorioamnionitis
(diagnosis)
- Female
- Fetal Membranes, Premature Rupture
- Finland
- Glucose
(analysis)
- Humans
- L-Lactate Dehydrogenase
(analysis)
- Pregnancy
- Prospective Studies
- Vagina
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