Effect of a hyaluronic acid and carboxymethylcellulose ophthalmic solution on ocular comfort and tear-film instability after cataract surgery.

Abstract

PURPOSE:

To evaluate the efficacy and safety of using sodium hyaluronate 0.1% and carboxymethylcellulose 0.5% artificial tears for ocular discomfort and tear-film stability in eyes after cataract surgery.

SETTING:

Twenty ophthalmic centers in Italy.

DESIGN:

Prospective randomized case series.

METHODS:

This study enrolled patients scheduled for unilateral cataract surgery. After surgery, patients received artificial tears and a topical steroid-antibiotic (study group) or topical steroid-antibiotic alone (control group) and were assessed postoperatively at 1 and 5 weeks. Outcome measures were tear breakup time (TBUT), ocular surface disease index (OSDI), frequency of dry-eye symptoms evaluated using a visual analog scale (VAS), and corneal fluorescein staining.

RESULTS:

The study comprised 282 patients. At 5 weeks, the mean TBUT was statistically significantly higher in the study group than in the control group (P = .0003). The mean OSDI score statistically significantly improved in both groups from 1 to 5 weeks (P < .0001 for both groups); however, there was no statistically significant difference between the groups at these timepoints. The artificial tears statistically significantly improved VAS-assessed dry-eye symptoms in the study group compared with the control group at 5 weeks (P < .001). The mean corneal fluorescein staining was significantly reduced in the study group compared with the control group at 5 weeks (P = .002 versus P = .05, respectively). No treatment-related adverse events were reported.

CONCLUSION:

Sodium hyaluronate 0.1% and carboxymethylcellulose 0.5% ophthalmic solution was effective and well tolerated in reducing dry-eye disease symptoms and improving the clinical outcome after cataract surgery.

FINANCIAL DISCLOSURE:

No author has a financial or proprietary interest in any material or method mentioned.

• Authors: Rita Mencucci, Carlotta Boccalini, Roberto Caputo, Eleonora Favuzza
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 41 Issue 8 Pg. 1699-704 (Aug 2015) ISSN: 1873-4502 [Electronic] United States
• PMID: 26432128 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Chemical References

• Drug Combinations
• Lubricant Eye Drops
• Ophthalmic Solutions
• Viscosupplements
• Hyaluronic Acid
• Carboxymethylcellulose Sodium

Topics

• Aged
• Carboxymethylcellulose Sodium (administration & dosage)
• Drug Combinations
• Dry Eye Syndromes (drug therapy, etiology, metabolism)
• Female
• Fluorophotometry
• Humans
• Hyaluronic Acid (administration & dosage)
• Lens Implantation, Intraocular
• Lubricant Eye Drops (administration & dosage)
• Male
• Ophthalmic Solutions
• Phacoemulsification (adverse effects)
• Prospective Studies
• Tears (metabolism)
• Viscosupplements (administration & dosage)
• Visual Analog Scale