Association between transcription factor 7-like 2 rs7903146 polymorphism and diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis.

Abstract

As one of the vascular complications of type 2 diabetes mellitus, the incidence of diabetes retinopathy is greatly increasing worldwide. Both genetic and environmental factors are involved in the pathologies. A meta-analysis was conducted to assess the association between transcription factor 7-like 2 polymorphism (rs7903146) and type 2 diabetic retinopathy. Published literature from PubMed, Web of Science and China National Knowledge Infrastructure were retrieved. Pooled odds ratios with 95% confidence intervals were calculated to estimate the strength of the association. Eight studies including 6422 participants were included in the final meta-analysis. Our analysis provides substantial evidence that the rs7903146 variant is significantly associated with the risk of diabetic retinopathy in Caucasian populations while not in East Asian populations. The variant of rs7903146 appeared more likely to be a promising genetic biomarker of diabetic retinopathy in Caucasians.

• Authors: Yuzhi Ding, Zizhong Hu, Songtao Yuan, Ping Xie, Qinghuai Liu
• Journal: Diabetes & vascular disease research (Diab Vasc Dis Res) Vol. 12 Issue 6 Pg. 436-44 (Nov 2015) ISSN: 1752-8984 [Electronic] England
• PMID: 26316572 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2015.

Chemical References

• Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
• TCF4 protein, human
• Transcription Factor 4
• Transcription Factors

Topics

• Asian People
• Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (genetics)
• China
• Diabetes Mellitus, Type 2 (complications, genetics)
• Diabetic Retinopathy (genetics)
• Genetic Predisposition to Disease
• Genotype
• Humans
• Polymorphism, Genetic (genetics)
• Risk Factors
• Transcription Factor 4
• Transcription Factors (genetics)
• White People