Abstract | AIM: To investigate the histological features of the liver in spontaneously diabetic Torii (SDT) fatty rats compared with age-matched Sprague-Dawley (SD) rats. METHODS: RESULTS: SDT fatty rats showed significantly increased body weight compared with SD rats. Serum glucose, TG, and TC levels were significantly higher in SDT fatty rats compared with SD rats. The serum AST and ALT levels in SDT fatty rats were significantly elevated at 8 wk of age compared with the levels in SD rats. Hepatic TG content was marked in SDT fatty rats from 8 to 32 wk of age. Histopathologically, severe hepatosteatosis accompanied by inflammation was observed at 8 wk of age, and fibrosis started to occur at 32 wk of age. Furthermore, Sirius Red and ED-1 staining were increased in the liver at 32 wk of age. Hepatic gene expression related to TG synthesis, inflammation and fibrosis tended to increase in SDT fatty rats compared with SD rats, and the gene expression related to TG secretion was decreased in SDT fatty rats compared with SD rats. CONCLUSION:
|
Authors | Yukihito Ishii, Yu Motohashi, Makoto Muramatsu, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Takahisa Yamada, Tohru Matsui, Shinichi Kume, Takeshi Ohta |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 21
Issue 30
Pg. 9067-78
(Aug 14 2015)
ISSN: 2219-2840 [Electronic] United States |
PMID | 26290633
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Biomarkers
- Blood Glucose
- Lipids
- RNA, Messenger
- Aspartate Aminotransferases
- Alanine Transaminase
|
Topics |
- Age Factors
- Alanine Transaminase
(blood)
- Animals
- Aspartate Aminotransferases
(blood)
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(blood, complications, genetics)
- Disease Models, Animal
- Female
- Gene Expression Regulation
- Lipids
(blood)
- Liver
(enzymology, pathology)
- Liver Cirrhosis, Experimental
(pathology)
- Non-alcoholic Fatty Liver Disease
(blood, etiology, genetics, pathology)
- Obesity
(blood, complications, genetics)
- RNA, Messenger
(metabolism)
- Rats, Inbred Strains
- Rats, Sprague-Dawley
- Severity of Illness Index
- Sex Factors
- Species Specificity
- Weight Gain
|