Multiple Colon Ulcers with Typical Small Intestinal Lesions Induced by Non-Steroidal Anti-Inflammatory Drugs.

Abstract

The diagnosis of NSAID-induced colon ulcers is difficult when the distribution or endoscopic findings are not typical. An 83-year-old woman was transferred to our hospital for hemorrhagic diarrhea. Colonoscopy showed multiple ulcers in the entire colon, particularly longitudinal ulcers in the transverse colon. These were unusual for NSAID-induced colopathy, although she had been on meloxicam. However, capsule endoscopy revealed multiple scars and erosions, characteristic of NSAIDs users. The final diagnosis was NSAID-induced enteropathy, and all lesions were in remission after meloxicam discontinuation. We herein emphasize the value of an endoscopic assessment of the entire digestive tract in the diagnosis of NSAID-induced mucosal lesions.

• Authors: Momoko Akashi, Takayuki Ando, Takeru Hamashima, Hiroki Yoshita, Sohachi Nanjo, Hiroshi Mihara, Haruka Fujinami, Shinya Kajiura, Jun Nishikawa, Yoshiaki Miura, Ayumu Hosokawa, Toshiro Sugiyama
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 54 Issue 16 Pg. 1995-9 ( 2015) ISSN: 1349-7235 [Electronic] Japan
• PMID: 26278290 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Thiazines
• Thiazoles
• Meloxicam

Topics

• Aged, 80 and over
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects)
• Capsule Endoscopy
• Colon (drug effects, pathology)
• Colonoscopy
• Female
• Gastrointestinal Hemorrhage (chemically induced, pathology)
• Humans
• Intestine, Small (drug effects, pathology)
• Meloxicam
• Thiazines (administration & dosage, adverse effects)
• Thiazoles (administration & dosage, adverse effects)
• Ulcer (chemically induced)