Abstract | OBJECTIVES: METHODS: We conducted an ancillary study on a previously published randomized trial of children undergoing CPB surgery. Serial blood glucose, insulin, and cytokines were drawn after CPB and at selected intervals for up to 48 hours after surgery. The primary outcome was plasma insulin levels and glucose-to- insulin ratio. Glucose delivery and feeding status were monitored for potential modifying effects. RESULTS: The 299 children studied were predominantly male (55%) with a median age of 2.7 (interquartile range [IQR]: 0.5-6.5) years, and weight of 12.6 (IQR: 6.4-10.8) kg. Operations had a median Society of Thoracic Surgery-European Association for Cardio-Thoracic Surgery complexity score of 1 (IQR: 1-2) and CPB time of 82 (IQR: 58-122) minutes. Hyperglycemia occurred in 85% of subjects; odds of hyperglycemia peaked at 6 hours after CPB. Plasma glucose was associated with increased insulin and a lower glucose-to- insulin ratio. Increased interleukin (IL)-6 concentrations were associated with increased glucose (estimate [EST]: 0.55 (±0.13) mmol/L; P < .001) and insulin (EST: 1.14 (±0.12) μmol/L; P < .001) in linear regression adjusted for repeated measures. Paradoxically, increased cytokines were associated with an increased glucose-to- insulin ratio (EST: 0.21 (±0.03) mmol/μmol; P < .001). CONCLUSIONS:
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Authors | Alejandro A Floh, Cedric Manlhiot, Andrew N Redington, Brian W McCrindle, Nadia A Clarizia, Christopher A Caldarone, Steven M Schwartz |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 150
Issue 3
Pg. 498-504.e1
(Sep 2015)
ISSN: 1097-685X [Electronic] United States |
PMID | 26190660
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Blood Glucose
- IL6 protein, human
- Inflammation Mediators
- Insulin
- Interleukin-6
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Topics |
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Cardiopulmonary Bypass
(adverse effects)
- Child
- Child, Preschool
- Female
- Humans
- Hyperglycemia
(blood, diagnosis, etiology)
- Infant
- Inflammation
(blood, diagnosis, etiology)
- Inflammation Mediators
(blood)
- Insulin
(blood)
- Insulin Resistance
- Interleukin-6
(blood)
- Linear Models
- Male
- Nutritional Status
- Odds Ratio
- Randomized Controlled Trials as Topic
- Risk Factors
- Time Factors
- Treatment Outcome
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