Analysis of the UHRF1 expression in serum and tissue for gastric cancer detection.

Abstract

OBJECTIVE:

To analyze the Ubiquitin-like with PHD and ring finger domains (UHRF) 1 expression in gastric cancer (GC).

METHODS:

The concentrations of UHRF1 DNA in serum were compared between 187 GC patients and 56 healthy controls using real-time PCR. Immunohistochemical analysis using tissue microarrays was performed.

RESULTS:

UHRF1 DNA levels were significantly higher in GC patients compared to healthy controls (p < 0.001) and have associations with age and lymph node metastasis (LNM). The UHRF1 expression was significantly higher in tumor tissue than matched normal tissues (p < 0.001).

CONCLUSIONS:

The UHRF1 expression in serum and tissue may represent a novel biomarker for GC diagnosis and prognosis.

• Authors: Mengyuan Ge, Zhen Gui, Xiaoming Wang, Feng Yan
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 20 Issue 3 Pg. 183-8 ( 2015) ISSN: 1366-5804 [Electronic] England
• PMID: 26161699 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• CCAAT-Enhancer-Binding Proteins
• DNA, Neoplasm
• UHRF1 protein, human
• Ubiquitin-Protein Ligases

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Base Sequence
• Biomarkers, Tumor (blood, genetics)
• CCAAT-Enhancer-Binding Proteins (blood, genetics)
• Case-Control Studies
• DNA, Neoplasm (blood, genetics)
• Female
• Gene Expression
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• Molecular Sequence Data
• Neoplasm Staging
• Prognosis
• Stomach Neoplasms (blood, diagnosis, genetics)
• Tissue Array Analysis
• Ubiquitin-Protein Ligases