Abstract | OBJECTIVE: METHODS: 83 adults with obesity undergoing BPD-DS, 45 obese non-surgical controls, and 9 lean surgical controls were enrolled. Plasma parameters and anthropometric measures were obtained at baseline and at, early (24 h, 5 D) and late (6 months and 12 months) post-operative stages. RESULTS: Plasma chemerin dropped from 176±49 ng/mL at baseline to 132±52 ng/mL 24 h after BPD-DS, rebounded to 200±66 ng/mL after 5 D, and declined to 124±51 and 110±34 ng/mL after 6 and 12 months. Plasma chemerin correlated negatively with measures of inflammation and hepatic injury and positively with measures of obesity, metabolic syndrome, and inflammation in the early and late post-operative periods, respectively. CONCLUSIONS: Chemerin has a novel role in surgical injury but not hyperglycemia resolution early after BPD-DS. Over the long term, plasma chemerin declines to a new set point that is partially determined by body fat reductions.
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Authors | Sebastian D Parlee, Yan Wang, Paul Poirier, Marc Lapointe, Julie Martin, Marjorie Bastien, Katherine Cianflone, Kerry B Goralski |
Journal | Obesity (Silver Spring, Md.)
(Obesity (Silver Spring))
Vol. 23
Issue 6
Pg. 1201-8
(Jun 2015)
ISSN: 1930-739X [Electronic] United States |
PMID | 25959026
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 The Obesity Society. |
Chemical References |
- Chemokines
- Intercellular Signaling Peptides and Proteins
- RARRES2 protein, human
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Topics |
- Adult
- Bariatric Surgery
- Biliopancreatic Diversion
- Body Mass Index
- Chemokines
(metabolism)
- Female
- Humans
- Intercellular Signaling Peptides and Proteins
(metabolism)
- Male
- Middle Aged
- Obesity, Morbid
(metabolism, surgery)
- Postoperative Period
- Treatment Outcome
- Young Adult
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