Abstract | INTRODUCTION: We performed a retrospective study on clinical assessment, tumor location, radiological imaging, histopathological characteristics, and therapeutic management of 7 patients affected by choroid plexus carcinoma ( CPC) or atypical choroid plexus papilloma (ACPP) who have been observed in the last 12 years. METHODS: Four patients fulfilled the criteria for classification as ACPP and three cases as CPC. The median age of the patients at the diagnosis was 42 months (range 3-190 months). Except one older patient (15 years old), all patients were younger than 3 years of age. In all patients affected by ACPP, a total surgical resection was achieved. Two children relapsed 12 and 8 months following radical removal. Both of them underwent adjuvant chemotherapy ( carboplatin, cyclophosphamide, etoposide, doxorubicin, and methotrexate); a complete remission was maintained in all cases. In all three patients with CPC, it was impossible to achieve complete resection at first surgery. The response to chemotherapy was variable: in one case, it was complete with complete remission following 6 months; in one case, it was partial with reduction on volume (the patient underwent second-look surgery with complete resection); in the third case, there was no response and the patient progressed and finally died with metastatic disease, 8 months after chemotherapy was started. For children with CPC, the OS was 75% at 6 years. RESULTS: In our series, surgery associated with chemotherapy led to long-term survival in 4/4 patients affected by ACPP and 2/3 patients affected by CPC. Clinical results achieved in our series confirm that our therapeutic regimen is feasible and efficient as a possible adjuvant treatment for both CPC and ACPP. It also suggests that surgery has a pivotal role in the management of most children affected by CPTs.
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Authors | Annalisa Passariello, Maria Tufano, Pietro Spennato, Lucia Quaglietta, Antonio Verrico, Roberta Migliorati, Giuseppe Cinalli |
Journal | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
(Childs Nerv Syst)
Vol. 31
Issue 7
Pg. 1079-88
(Jul 2015)
ISSN: 1433-0350 [Electronic] Germany |
PMID | 25863950
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Carcinoma
(diagnosis, drug therapy, surgery)
- Child, Preschool
- Choroid Plexus
(pathology)
- Choroid Plexus Neoplasms
(diagnosis, drug therapy, surgery)
- Female
- Follow-Up Studies
- Humans
- Infant
- Magnetic Resonance Imaging
- Male
- Papilloma, Choroid Plexus
(diagnosis, drug therapy, surgery)
- Retrospective Studies
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