Lipid-rich
carcinoma of the breast is extremely rare with no standard guidelines for treatment with poor patient prognosis. In the present study, the clinical features, imaging results, pathology, immunohistochemistry, treatment and prognoses of two patients with
lipid-rich
carcinoma of the breast were analyzed. Two patients were admitted to the Yantai Yuhuangding Hospital Affiliated to the Medical College of Qingdao University (Yantai, Shandong, China) for examination of a palpable mass in the breast. Enlarged lymph nodes were found in the axilla of each patient. The results of mammography and echography imaging suggested the presence of
malignancy. A
modified radical mastectomy was performed in each patient, and pathological examination revealed atypical large vacuolated cells arranged in clusters and confirmed
lipid-rich
carcinoma and
lymph node metastases. The
tumor tissue of patient one was immunohistochemically positive for
estrogen receptor (ER), p53, p120 and
E-cadherin, and negative for
progesterone receptor (PR) and
human epidermal growth factor receptor 2 (HER-2), with a Ki-67 labeling index of 50%. The
tumor tissue of patient two was immunohistochemically positive for p53, and negative for ER, PR, HER-2 and
cytokeratin 5/6, with a Ki-67 labeling index of 30%. Post-surgery, patient one was administered
chemotherapy for six cycles,
radiotherapy and endocrine
therapy in the form of
anastrozole. Patient two was administered three cycles of
chemotherapy without
radiotherapy. Subsequent to being followed up for 25 months and 13 months, respectively, there was no evidence of recurrence or distant
metastasis in patient one or two, respectively.