Abstract | OBJECTIVES: DESIGN AND METHODS: Our study included 1,749 French-Canadians aged 9, 13 and 16 years and evaluated 24 HNF4A polymorphisms that were previously identified by sequencing. RESULTS: Analyses revealed that, after correction for multiple testing, one SNP (rs736824; P<0.022) and two haplotypes (P1 promoter haplotype rs6130608-rs2425637; P<0.032 and intronic haplotype rs736824-rs745975-rs3212183; P<0.025) were associated with the risk of MetS. Additionally, a significant association was found between rs3212172 and apolipoprotein B levels (coefficient: -0.14 ± 0.05; P<0.022). These polymorphisms are located in HNF4A P1 promoter or in intronic regions. CONCLUSIONS: Our study demonstrates that HNF4α genetic variants are associated with the MetS and metabolic parameters in French Canadian children and adolescents. This study, the first exploring the relation between HNF4A genetic variants and MetS and metabolic variables in a pediatric cohort, suggests that HNF4α could represent an early marker for the risk of developing type 2 diabetes mellitus.
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Authors | Valérie Marcil, Devendra Amre, Ernest G Seidman, François Boudreau, Fernand P Gendron, Daniel Ménard, Jean François Beaulieu, Daniel Sinnett, Marie Lambert, Emile Levy |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 2
Pg. e0117238
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25671620
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Hepatocyte Nuclear Factor 4
- Insulin
- Lipids
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Topics |
- Adolescent
- Blood Glucose
(metabolism)
- Canada
(epidemiology, ethnology)
- Child
- Female
- Haplotypes
- Hepatocyte Nuclear Factor 4
(genetics)
- Humans
- Insulin
(blood)
- Lipids
(blood)
- Male
- Metabolic Syndrome
(blood, epidemiology, genetics)
- Polymorphism, Single Nucleotide
- White People
(genetics)
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