Abstract | BACKGROUND & AIMS: METHODS: We performed a retrospective study of 110 patients with alcohol-associated cirrhosis (77% male; mean age, 55 y; 71% with >6 mo of abstinence) who received liver transplants at a single center in Paris, France, from 2000 through 2013. We collected data on previous exposure to MRFs, steatosis (>10% in the explant), and histologically confirmed hepatocellular carcinoma (HCC). RESULTS: HCC was detected in explants from 29 patients (26%). Steatosis was detected in explants from 47 patients (70% were abstinent for ≥6 mo); 50% had a history of overweight or type 2 diabetes. Fifty-two patients (47%) had a history of MRFs and therefore were at risk for nonalcoholic fatty liver disease. A higher proportion of patients with MRF had HCC than those without MRF (46% vs 9%; P < .001). A previous history of overweight or type 2 diabetes significantly increased the risk for HCC (odds ratio, 6.23; 95% confidence interval [CI], 2.47-15.76, and odds ratio, 4.63; 95% CI, 1.87-11.47, respectively; P < .001). MRF, but not steatosis, was associated with the development of HCC (odds ratio, 11.76; 95% CI, 2.60-53; P = .001) independent of age, sex, amount of alcohol intake, or severity of liver disease. CONCLUSIONS:
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Authors | Raluca Pais, Pascal Lebray, Geraldine Rousseau, Frédéric Charlotte, Ghizlaine Esselma, Eric Savier, Dominique Thabut, Marika Rudler, Daniel Eyraud, Corinne Vezinet, Jean-Michel Siksik, Jean-Christophe Vaillant, Laurent Hannoun, Thierry Poynard, Vlad Ratziu |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 13
Issue 5
Pg. 992-9.e2
(May 2015)
ISSN: 1542-7714 [Electronic] United States |
PMID | 25459558
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Carcinoma, Hepatocellular
(epidemiology)
- Diabetes Mellitus, Type 2
(complications, epidemiology)
- Fatty Liver
(complications, epidemiology)
- Female
- France
(epidemiology)
- Humans
- Liver Cirrhosis, Alcoholic
(complications)
- Liver Neoplasms
(epidemiology)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(complications)
- Obesity
(complications, epidemiology)
- Paris
- Prevalence
- Retrospective Studies
- Risk Assessment
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