Abstract |
The thyroid function of 44 subjects with Down syndrome who were between 2 and 51 years of age was assessed. Three patients (7%) had hypothyroidism, and in 2 of them high titers of antimicrosomal antibody were detected. Seven additional subjects (16%) had low-borderline thyroid function, 6 with elevated thyroid stimulating hormone. These 7 subjects constituted the cohort for an evaluation of the short-term benefits of thyroid hormone supplementation in the low-borderline thyroid functional state. A double-blind crossover drug placebo trial failed to document any cognitive, social, response time, or physical changes attributable to the 8- to 14-week drug treatment period compared to an untreated matched control group. Results provided no evidence for the efficacy of short-term thyroid hormone therapy for this population.
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Authors | E Tirosh, Y Taub, A Scher, M Jaffe, Z Hochberg |
Journal | American journal of mental retardation : AJMR
(Am J Ment Retard)
Vol. 93
Issue 6
Pg. 652-6
(May 1989)
ISSN: 0895-8017 [Print] United States |
PMID | 2524203
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Behavior
(drug effects)
- Child
- Child, Preschool
- Down Syndrome
(complications)
- Female
- Humans
- Hypothyroidism
(complications, drug therapy)
- Male
- Middle Aged
- Thyroxine
(pharmacology)
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